日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer.

IL-6 预测 CDK4/6 抑制剂耐药性,确定 STAT3 为 HR+/HER2 阴性转移性乳腺癌的靶点

Kettner Nicole M, Bui Tuyen N, Navarro-Yepes Juliana, Ghotbaldini Sanaz, Quintela Bethanie, Luo Catherine K, Lam Nghi, Rao Xiayu, Raghavendra Akshara Singareeka, Wang Yan, Azizian Nancy, Kris Eckols T, Kasembeli Moses Makokha, Evans Kurt, Yi Min, Wingate Hannah, Wang Jing, Sahin Aysegul A, Meric-Bernstam Funda, Hunt Kelly K, Damodaran Senthil, Tweardy David J, Tripathy Debu, Keyomarsi Khandan

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.

选择性抑制经典 STAT3 信号传导可抑制 K-ras 突变肺肿瘤的发生,并重新激发抗肿瘤免疫力

Clowers Michael J, Rahal Zahraa, Cho Sung-Nam, Krishna Avantika, Yuan Bo, Hamana Zorrilla Leticia G, Eckols T Kris, Kasembeli Moses M, Liu Samuel, Peng Stephen, Ramos-Castaneda Marco, Thompson Annamarie L, Rodriguez Reyna Carlos Ignacio, Larsen Katherine E, Grimaldo Maria T, Deng Shanshan, Karimi Nastaran, Chou Cody, Velasco Walter V, Zarghooni Melody, Alekseev Sayan, Solis Soto Luisa M, Ostrin Edwin J, Kadara Humam, Ekmekcioglu Suhendan, Tweardy David J, Moghaddam Seyed Javad

STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer

STAT3抑制剂治疗溃疡性结肠炎相关结直肠癌

Robinson, Prema; Italia, Zal; Italia, Zara; Hoang, Tan; Rodriguez, Emma; Eckols, T Kris; Kasembeli, Moses; Zorrilla, Leticia Hamana; Soto, Luisa Maren Solis; Mahalingam, Rajasekaran; Tweardy, David J

Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis

小分子 STAT3 抑制剂在小鼠结肠炎模型中的治疗潜力

Prema Robinson, Kelsey Montoya, Emily Magness, Emma Rodriguez, Viviana Villalobos, Nikita Engineer, Peng Yang, Uddalak Bharadwaj, Thomas Kris Eckols, David John Tweardy

Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Crohn's Disease

克罗恩病小鼠模型中 Stat3 的基因和小分子调控

Robinson, Prema; Magness, Emily; Montoya, Kelsey; Engineer, Nikita; Eckols, Thomas K; Rodriguez, Emma; Tweardy, David J

Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility

通过结合 SH2 结构域灵活性的基于结构的虚拟配体筛选鉴定出新型 STAT3 小分子抑制剂

Ren Kong, Uddalak Bharadwaj, T Kris Eckols, Mikhail Kolosov, Haoyi Wu, Francisco J Santa Cruz-Pavlovich, Alison Shaw, Oluwatomilona I Ifelayo, Hong Zhao, Moses M Kasembeli, Stephen T C Wong, David J Tweardy

Substance P Antagonism Prevents Chemotherapy-Induced Cardiotoxicity

P物质拮抗剂可预防化疗引起的心脏毒性

Legi, Ashiq; Rodriguez, Emma; Eckols, Thomas K; Mistry, Cyrus; Robinson, Prema

Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease

阻断慢性肾病大鼠肌肉蛋白水解的 STAT3 抑制剂 TTI-101 的药代动力学和药效学

Liping Zhang, Ying Wang, Yanlan Dong, Zihong Chen, Thomas K Eckols, Moses M Kasembeli, David J Tweardy, William E Mitch

Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer

在帕博西尼耐药的ER阳性乳腺癌中,STAT3和DNA修复的联合抑制

Kettner, Nicole M; Vijayaraghavan, Smruthi; Durak, Merih Guray; Bui, Tuyen; Kohansal, Mehrnoosh; Ha, Min Jin; Liu, Bin; Rao, Xiayu; Wang, Jing; Yi, Min; Carey, Jason P W; Chen, Xian; Eckols, T Kris; Raghavendra, Akshara S; Ibrahim, Nuhad K; Karuturi, Meghan Sri; Watowich, Stephanie S; Sahin, Aysegul; Tweardy, David J; Hunt, Kelly K; Tripathy, Debu; Keyomarsi, Khandan

Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

更正:小分子抑制剂对放射抗性头颈部鳞状细胞癌中 STAT3 的抑制作用

Bharadwaj, Uddalak; Eckols, T Kris; Xu, Xuejun; Kasembeli, Moses M; Chen, Yunyun; Adachi, Makoto; Song, Yongcheng; Mo, Qianxing; Lai, Stephen Y; Tweardy, David J