日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of a targeted BioPROTAC degrader selective for misfolded SOD1

开发一种针对错误折叠的SOD1的靶向BioPROTAC降解剂

Chisholm, Christen G; Bartlett, Rachael; Brown, Mikayla L; Proctor, Emma-Jayne; Farrawell, Natalie E; Gorman, Jody; Delerue, Fabien; Ittner, Lars M; Vine-Perrow, Kara L; Ecroyd, Heath; Cashman, Neil R; Saunders, Darren N; McAlary, Luke; Lum, Jeremy S; Yerbury, Justin J

A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis.

多药联合疗法对治疗 SOD1 相关肌萎缩侧索硬化症具有疗效

Lum Jeremy S, Brown Mikayla L, Farrawell Natalie E, Bartlett Rachael, Chisholm Christen G, Gorman Jody, Dosseto Anthony, Dux Florian, McInnes Lachlan E, Ecroyd Heath, McAlary Luke, Crouch Peter J, Donnelly Paul S, Yerbury Justin J

Competing chaperone pathways in α-synuclein disaggregation and aggregation dynamics.

α-突触核蛋白解聚和聚集动力学中的竞争性分子伴侣通路。

Auld Nicola K, McMahon Shannon, Marzano Nicholas R, van Oijen Antoine M, Ecroyd Heath

Single-molecule observations of human small heat shock proteins in complex with aggregation-prone client proteins.

利用单分子方法观察人类小热休克蛋白与易聚集底物蛋白的复合物

Rice Lauren, Marzano Nicholas, Cox Dezerae, Skewes Bailey, van Oijen Antoine M, Ecroyd Heath

The beauty and complexity of the small heat shock proteins: a report on the proceedings of the fourth workshop on small heat shock proteins

小分子热休克蛋白之美与复杂性:第四届小分子热休克蛋白研讨会论文集报告

Ecroyd, Heath; Bartelt-Kirbach, Britta; Ben-Zvi, Anat; Bonavita, Raffaella; Bushman, Yevheniia; Casarotto, Elena; Cecconi, Ciro; Lau, Wilson Chun Yu; Hibshman, Jonathan D; Joosten, Joep; Kimonis, Virginia; Klevit, Rachel; Liberek, Krzysztof; McMenimen, Kathryn A; Miwa, Tsukumi; Mogk, Axel; Montepietra, Daniele; Peters, Carsten; Rocchetti, Maria Teresa; Saman, Dominik; Sisto, Angela; Secco, Valentina; Strauch, Annika; Taguchi, Hideki; Tanguay, Morgan; Tedesco, Barbara; Toth, Melinda E; Wang, Zihao; Benesch, Justin L P; Carra, Serena

Real-time single-molecule observation of chaperone-assisted protein folding

实时单分子观测分子伴侣辅助的蛋白质折叠

Marzano, Nicholas R; Paudel, Bishnu P; van Oijen, Antoine M; Ecroyd, Heath

Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health

男性和女性生殖细胞系中的蛋白质稳态:维持生殖健康的新视角

Cafe, Shenae L; Nixon, Brett; Ecroyd, Heath; Martin, Jacinta H; Skerrett-Byrne, David A; Bromfield, Elizabeth G

Illuminating amyloid fibrils: Fluorescence-based single-molecule approaches

揭示淀粉样蛋白原纤维:基于荧光的单分子方法

Rice, Lauren J; Ecroyd, Heath; van Oijen, Antoine M

De Novo Design, Synthesis, and Mechanistic Evaluation of Short Peptides That Mimic Heat Shock Protein 27 Activity

从头设计、合成和机制评价模拟热休克蛋白27活性的短肽

Kho, Jessica; Pham, P Chi; Kwon, Suhyeon; Huang, Alana Y; Rivers, Joel P; Wang, Huixin; Ecroyd, Heath; Donald, W Alexander; McAlpine, Shelli R

Single-molecule fluorescence-based approach reveals novel mechanistic insights into human small heat shock protein chaperone function.

基于单分子荧光的方法揭示了人类小热休克蛋白分子伴侣功能的新机制见解

Johnston Caitlin L, Marzano Nicholas R, Paudel Bishnu P, Wright George, Benesch Justin L P, van Oijen Antoine M, Ecroyd Heath