日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-resolution functional mapping of RAD51C by saturation genome editing

利用饱和基因组编辑技术对 RAD51C 进行高分辨率功能定位

Rebeca Olvera-León,Fang Zhang,Victoria Offord,Yajie Zhao,Hong Kee Tan,Prashant Gupta,Tuya Pal,Carla Daniela Robles-Espinoza,Fernanda G Arriaga-González,Larissa Satiko Alcantara Sekimoto Matsuyama,Erwan Delage,Ed Dicks,Suzana Ezquina,Charlie F Rowlands,Clare Turnbull,Paul Pharoah,John R B Perry,Maria Jasin,Andrew J Waters,David J Adams

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

鉴定出 12 个针对不同组织型上皮性卵巢癌的新易感基因位点

Catherine M Phelan, Karoline B Kuchenbaecker, Jonathan P Tyrer, Siddhartha P Kar, Kate Lawrenson, Stacey J Winham, Joe Dennis, Ailith Pirie, Marjorie J Riggan, Ganna Chornokur, Madalene A Earp, Paulo C Lyra Jr, Janet M Lee, Simon Coetzee, Jonathan Beesley, Lesley McGuffog, Penny Soucy, Ed Dicks, And

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

6q25 乳腺癌风险变异表现出不同的表型关联并调节 ESR1、RMND1 和 CCDC170

Alison M Dunning, Kyriaki Michailidou, Karoline B Kuchenbaecker, Deborah Thompson, Juliet D French, Jonathan Beesley, Catherine S Healey, Siddhartha Kar, Karen A Pooley, Elena Lopez-Knowles, Ed Dicks, Daniel Barrowdale, Nicholas A Sinnott-Armstrong, Richard C Sallari, Kristine M Hillman, Susanne Kau

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

有证据表明 2q35 基因座的乳腺癌风险是通过 IGFBP5 调节介导的

Maya Ghoussaini, Stacey L Edwards, Kyriaki Michailidou, Silje Nord, Richard Cowper-Sal Lari, Kinjal Desai, Siddhartha Kar, Kristine M Hillman, Susanne Kaufmann, Dylan M Glubb, Jonathan Beesley, Joe Dennis, Manjeet K Bolla, Qin Wang, Ed Dicks, Qi Guo, Marjanka K Schmidt, Mitul Shah, Robert Luben, Jud

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

乳腺癌 11q13 风险位点的功能变异通过长程增强子调节细胞周期蛋白 D1 的表达

Juliet D French, Maya Ghoussaini, Stacey L Edwards, Kerstin B Meyer, Kyriaki Michailidou, Shahana Ahmed, Sofia Khan, Mel J Maranian, Martin O'Reilly, Kristine M Hillman, Joshua A Betts, Thomas Carroll, Peter J Bailey, Ed Dicks, Jonathan Beesley, Jonathan Tyrer, Ana-Teresa Maia, Andrew Beck, Nicholas