日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

通过全基因组测序解析FTLD-TDP病理亚型的不同遗传风险因素

Pottier, Cyril; Küçükali, Fahri; Baker, Matt; Batzler, Anthony; Jenkins, Gregory D; van Blitterswijk, Marka; Vicente, Cristina T; De Coster, Wouter; Wynants, Sarah; Van de Walle, Pieter; Ross, Owen A; Murray, Melissa E; Faura, Júlia; Haggarty, Stephen J; van Rooij, Jeroen Gj; Mol, Merel O; Hsiung, Ging-Yuek R; Graff, Caroline; Öijerstedt, Linn; Neumann, Manuela; Asmann, Yan; McDonnell, Shannon K; Baheti, Saurabh; Josephs, Keith A; Whitwell, Jennifer L; Bieniek, Kevin F; Forsberg, Leah; Heuer, Hilary; Lago, Argentina Lario; Geier, Ethan G; Yokoyama, Jennifer S; Oddi, Alexis P; Flanagan, Margaret; Mao, Qinwen; Hodges, John R; Kwok, John B; Domoto-Reilly, Kimiko; Synofzik, Matthis; Wilke, Carlo; Onyike, Chiadi; Dickerson, Bradford C; Evers, Bret M; Dugger, Brittany N; Munoz, David G; Keith, Julia; Zinman, Lorne; Rogaeva, Ekaterina; Suh, EunRan; Gefen, Tamar; Geula, Changiz; Weintraub, Sandra; Diehl-Schmid, Janine; Farlow, Martin R; Edbauer, Dieter; Woodruff, Bryan K; Caselli, Richard J; Donker Kaat, Laura L; Huey, Edward D; Reiman, Eric M; Mead, Simon; King, Andrew; Roeber, Sigrun; Nana, Alissa L; Ertekin-Taner, Nilufer; Knopman, David S; Petersen, Ronald C; Petrucelli, Leonard; Uitti, Ryan J; Wszolek, Zbigniew K; Ramos, Eliana Marisa; Grinberg, Lea T; Tempini, Maria Luisa Gorno; Rosen, Howard J; Spina, Salvatore; Piguet, Olivier; Grossman, Murray; Trojanowski, John Q; Keene, C Dirk; Jin, Lee-Way; Prudlo, Johannes; Geschwind, Daniel H; Rissman, Robert A; Cruchaga, Carlos; Ghetti, Bernardino; Halliday, Glenda M; Beach, Thomas G; Serrano, Geidy E; Arzberger, Thomas; Herms, Jochen; Boxer, Adam L; Honig, Lawrence S; Vonsattel, Jean P; Lopez, Oscar L; Kofler, Julia; White, Charles L 3rd; Gearing, Marla; Glass, Jonathan; Rohrer, Jonathan D; Irwin, David J; Lee, Edward B; Van Deerlin, Vivianna; Castellani, Rudolph; Mesulam, Marsel M; Tartaglia, Maria C; Finger, Elizabeth C; Troakes, Claire; Al-Sarraj, Safa; Dalgard, Clifton L; Miller, Bruce L; Seelaar, Harro; Graff-Radford, Neill R; Boeve, Bradley F; Mackenzie, Ian Ra; van Swieten, John C; Seeley, William W; Sleegers, Kristel; Dickson, Dennis W; Biernacka, Joanna M; Rademakers, Rosa

Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice.

纠正脂质代谢紊乱可使少突胶质细胞中的基因表达正常化,并延长雌性 poly-GA C9orf72 小鼠的寿命

Rezaei Ali, Kocsis-Jutka Virág, Gunes Zeynep I, Zeng Qing, Kislinger Georg, Bauernschmitt Franz, Isilgan Huseyin Berkcan, Parisi Laura R, Kaya Tuğberk, Franzenburg Sören, Koppenbrink Jonas, Knogler Julia, Arzberger Thomas, Farny Daniel, Nuscher Brigitte, Katona Eszter, Dhingra Ashutosh, Yang Chao, Gouna Garyfallia, LaClair Katherine D, Janjic Aleksandar, Enard Wolfgang, Zhou Qihui, Hagan Nellwyn, Ofengeim Dimitry, Beltrán Eduardo, Gokce Ozgun, Simons Mikael, Liebscher Sabine, Edbauer Dieter

Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control.

比较 CRISPRi 筛选揭示了人类干细胞对 mRNA 翻译偶联质量控制的依赖性。

Rodschinka Geraldine, Forcelloni Sergio, Kühner Felix M, Wani Sascha, Riemenschneider Henrick, Edbauer Dieter, Behrens Andrew, Nedialkova Danny D

Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding

TDP-43与Tau蛋白的直接相互作用促进二者的共凝聚,同时抑制Tau蛋白原纤维的形成和成核作用。

Francesca Simonetti ,Weijia Zhong,Saskia Hutten,Federico Uliana,Martina Schifferer,Ali Rezaei,Lisa Marie Ramirez ,Janine Hochmair,Rithika Sankar,Anusha Gopalan ,Fridolin Kielisch,Henrick Riemenschneider,Viktoria Ruf,Carla Schmidt,Mikael Simons ,Markus Zweckstetter ,Susanne Wegmann,Tammaryn Lashley,Magdalini Polymenidou,Dieter Edbauer ,Dorothee Dormann

Micro- and nanoplastics reduce the phagocytosis and intracellular killing of E. coli by THP1-Blue™ NFκB monocytes

微塑料和纳米塑料会降低THP1-Blue™ NFκB单核细胞对大肠杆菌的吞噬作用和细胞内杀灭作用。

Edbauer, Florian; Ludwig, Hans-Christoph; Moritz, Marie Julia; Nau, Roland; Seele, Jana

Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits

内源性 TDP-43 的错误定位导致类似 ALS 的早期代谢功能障碍和进行性运动障碍

Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid

Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects

由于 C9orf72 功能丧失而导致的 Poly-GP 积累通过自噬和线粒体自噬缺陷诱导运动神经元凋亡

Hortense de Calbiac, Solène Renault, Grégoire Haouy, Vincent Jung, Kevin Roger, Qihui Zhou, Maria-Letizia Campanari, Loïc Chentout, Doris Lou Demy, Anca Marian, Nicolas Goudin, Dieter Edbauer, Chiara Guerrera, Sorana Ciura, Edor Kabashi

Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons

作者更正:TDP-43 C端片段的凝胶状包涵体可隔离神经元中停滞的蛋白酶体。

Riemenschneider, Henrick; Guo, Qiang; Bader, Jakob; Frottin, Frédéric; Farny, Daniel; Kleinberger, Gernot; Haass, Christian; Mann, Matthias; Hartl, F Ulrich; Baumeister, Wolfgang; Hipp, Mark S; Meissner, Felix; Fernández-Busnadiego, Rubén; Edbauer, Dieter

Development and Preclinical Evaluation of a Copper-64-Labeled Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

开发和临床前评估靶向甘氨酸-丙氨酸二肽的铜-64标记抗体用于C9orf72相关肌萎缩侧索硬化症/额颞叶痴呆的PET成像

Shojaei, Monireh; Zhou, Qihui; Palumbo, Giovanna; Schaefer, Rebecca; Kaskinoro, Janne; Vehmaan-Kreula, Pirjo; Bartenstein, Peter; Brendel, Matthias; Edbauer, Dieter; Lindner, Simon

A dataset profiling the multiomic landscape of the prefrontal cortex in amyotrophic lateral sclerosis

肌萎缩侧索硬化症前额皮质多组学图谱的数据集

Hausmann, Fabian; Caldi Gomes, Lucas; Hänzelmann, Sonja; Khatri, Robin; Oller, Sergio; Gebelin, Marie; Parvaz, Mojan; Tzeplaeff, Laura; Pasetto, Laura; Zhou, Qihui; Zelina, Pavol; Edbauer, Dieter; Pasterkamp, R Jeroen; Rehrauer, Hubert; Schlapbach, Ralph; Carapito, Christine; Bonetto, Valentina; Bonn, Stefan; Lingor, Paul