日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase

冠状病毒nsp14甲基转移酶双底物抑制剂的晶体学表征和开发

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md00896d
Georgiou, Irene; Robinson, Colin; O'Byrne, Sean N; Matsuda, Alex; Grygier, Przemysław; Smith, Craig D; O'Neill, Sandra; Ahmad, Shamshad A; Norval, Suzanne; Post, John M; Groenewold, Mirjam; Urakova, Nadya; Wanningen, Patrick; Kresik, Leanid; Plewka, Jacek; Delpal, Adrien; See, Kexin; Eadsforth, Thomas; Wierzbicka, Kinga; Decroly, Etienne; Saikatendu, Kumar Singh; Chang, Edcon; Snijder, Eric J; Pyrć, Krzysztof; Czarna, Anna; Scott, Duncan E; Gilbert, Ian H
微生物学
发表日期：2026
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Discovery of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 Main Protease through Computer-Aided Drug Design

利用计算机辅助药物设计发现SARS-CoV-2主蛋白酶的高效非共价抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01199
Okabe, Atsutoshi; Carney, Daniel W; Tawada, Michiko; Akther, Thamina; Aida, Jumpei; Takagi, Terufumi; Dougan, Douglas R; Leffler, Abba E; Bell, Jeffrey A; Frye, Leah; Hickey, Eugene R; Komandla, Mallareddy; Tao, Will; Selimkhanov, Jangir; Yonemori, Kazuko; Chang, Edcon; Saikatendu, Kumar; Ochida, Atsuko
SARS-CoV-2
发表日期：2025
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More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

不仅仅是酰胺生物电子等排体：发现含 1,2,4-三唑的吡唑并[1,5- a]嘧啶宿主 CSNK2 抑制剂用于对抗 β-冠状病毒复制

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c00962
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael M Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David H Drewry, Timothy M Willson
免疫
微生物学
IF2B
发表日期：2024
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Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2

通过战略性氟化获得强效、选择性、代谢稳定且口服生物可利用的 CSNK2 抑制剂

期刊:Molecules
影响因子:4.2
doi:10.3390/molecules29174158
Han Wee Ong, Xuan Yang, Jeffery L Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J Dickmander, Tammy M Havener, Marcia K Sanders, Jason W Brown, Rafael M Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David H Drewry, Timothy M Willson
代谢
发表日期：2024
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Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

色胺酮类似物以亚化学计量比抑制有种子和无种子 Tau4RD 聚集

期刊:
影响因子:
doi:10.1101/2024.02.02.578649
James, Ellie I; Baggett, David W; Chang, Edcon; Schachter, Joel; Nixey, Thomas; Choi, Karoline; Guttman, Miklos; Nath, Abhinav
发表日期：2024
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Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors

利用变构抑制剂发现SARS-CoV-2 nsp16中一个可成药的隐蔽口袋

期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.3c00203
Inniss, Nicole L; Kozic, Ján; Li, Fengling; Rosas-Lemus, Monica; Minasov, George; Rybáček, Jiří; Zhu, Yingjie; Pohl, Radek; Shuvalova, Ludmilla; Rulíšek, Lubomír; Brunzelle, Joseph S; Bednárová, Lucie; Štefek, Milan; Kormaník, Ján Michael; Andris, Erik; Šebestík, Jaroslav; Li, Alice Shi Ming; Brown, Peter J; Schmitz, Uli; Saikatendu, Kumar; Chang, Edcon; Nencka, Radim; Vedadi, Masoud; Satchell, Karla J F
SARS-CoV-2
发表日期：2023
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Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5- a]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A

优化 3-氰基-7-环丙基氨基-吡唑并[1,5- a]嘧啶以开发 CSNK2A 体内化学探针

期刊:ACS Omega
影响因子:3.7
doi:10.1021/acsomega.3c05377
Xuan Yang, Han Wee Ong, Rebekah J Dickmander, Jeffery L Smith, Jason W Brown, William Tao, Edcon Chang, Nathaniel J Moorman, Alison D Axtman, Timothy M Willson
信号转导
发表日期：2023
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Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses

宿主激酶 CSNK2 是抑制致病性 SARS 样 β 冠状病毒的靶点

期刊:ACS Chemical Biology
影响因子:3.5
doi:10.1021/acschembio.2c00378
Xuan Yang, Rebekah J Dickmander, Armin Bayati, Sharon A Taft-Benz, Jeffery L Smith, Carrow I Wells, Emily A Madden, Jason W Brown, Erik M Lenarcic, Boyd L Yount Jr, Edcon Chang, Alison D Axtman, Ralph S Baric, Mark T Heise, Peter S McPherson, Nathaniel J Moorman, Timothy M Willson
微生物学
发表日期：2022
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