日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

不仅仅是酰胺生物电子等排体:发现含 1,2,4-三唑的吡唑并[1,5- a]嘧啶宿主 CSNK2 抑制剂用于对抗 β-冠状病毒复制

Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael M Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David H Drewry, Timothy M Willson

Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2

通过战略性氟化获得强效、选择性、代谢稳定且口服生物可利用的 CSNK2 抑制剂

Han Wee Ong, Xuan Yang, Jeffery L Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J Dickmander, Tammy M Havener, Marcia K Sanders, Jason W Brown, Rafael M Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David H Drewry, Timothy M Willson

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5- a]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A

优化 3-氰基-7-环丙基氨基-吡唑并[1,5- a]嘧啶以开发 CSNK2A 体内化学探针

Xuan Yang, Han Wee Ong, Rebekah J Dickmander, Jeffery L Smith, Jason W Brown, William Tao, Edcon Chang, Nathaniel J Moorman, Alison D Axtman, Timothy M Willson

Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses

宿主激酶 CSNK2 是抑制致病性 SARS 样 β 冠状病毒的靶点

Xuan Yang, Rebekah J Dickmander, Armin Bayati, Sharon A Taft-Benz, Jeffery L Smith, Carrow I Wells, Emily A Madden, Jason W Brown, Erik M Lenarcic, Boyd L Yount Jr, Edcon Chang, Alison D Axtman, Ralph S Baric, Mark T Heise, Peter S McPherson, Nathaniel J Moorman, Timothy M Willson