日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tethered Exosomes Containing the Matrix Metalloproteinase MT1-MMP Contribute to Extracellular Matrix Degradation.

含有基质金属蛋白酶 MT1-MMP 的系链外泌体有助于细胞外基质降解

Palmulli Roberta, Jackson Hannah K, Edgar James R

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease

一种新型的人类胎肺来源的肺泡类器官模型揭示了与间质性肺疾病相关的表面活性蛋白C成熟的机制。

Lim, Kyungtae; Rutherford, Eimear N; Delpiano, Livia; He, Peng; Lin, Weimin; Sun, Dawei; Van den Boomen, Dick J H; Edgar, James R; Bang, Jae Hak; Predeus, Alexander; Teichmann, Sarah A; Marioni, John C; Matesic, Lydia E; Lee, Joo-Hyeon; Lehner, Paul J; Marciniak, Stefan J; Rawlins, Emma L; Dickens, Jennifer A

Encephalomyocarditis virus protein 2B* interacts with 14-3-3 proteins through a phosphorylated C-terminal binding motif.

脑心肌炎病毒蛋白 2B* 通过磷酸化的 C 端结合基序与 14-3-3 蛋白相互作用

Nguyen Samantha K, Anders Nadine, Holmes Stephen, Barrow Henry G, Lukhovitskaya Nina, Jahun Aminu S, Georgana Iliana, Caller Laura G, Edgar James R, Graham Stephen C, Emmott Edward, Firth Andrew E, Stewart Hazel

Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing.

肺泡类器官的内源基因编辑显示,致病变异体 SFTPC-I73T 的表达会破坏内体功能、上皮极性和伤口愈合

Rutherford Eimear N, Sun Dawei, Lim Kyungtae, Edgar James R, Matesic Lydia E, Marciniak Stefan J, Rawlins Emma L, Dickens Jennifer A

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development.

调节性 T 细胞中缺乏磷脂酰肌醇 3-激酶 VPS34 会导致致命的淋巴增生性疾病,但并不影响其发育

Courreges Christina J F, Davenport Elizabeth C M, Bilanges Benoit, Rebollo-Gomez Elena, Hukelmann Jens, Schoenfelder Priya, Edgar James R, Sansom David, Scudamore Cheryl L, Roychoudhuri Rahul, Garden Oliver A, Vanhaesebroeck Bart, Okkenhaug Klaus

Exploiting Connections for Viral Replication

利用连接进行病毒复制

Wong, Louise H; Edgar, James R; Martello, Andrea; Ferguson, Brian J; Eden, Emily R

Q&A: What are exosomes, exactly?

问答:外泌体究竟是什么?

Edgar, James R

Fractionation profiling: a fast and versatile approach for mapping vesicle proteomes and protein-protein interactions

分级分离分析:一种快速且通用的囊泡蛋白质组和蛋白质-蛋白质相互作用图谱绘制方法

Borner, Georg H H; Hein, Marco Y; Hirst, Jennifer; Edgar, James R; Mann, Matthias; Robinson, Margaret S