日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

In situ targeted base editing of bacteria in the mouse gut

小鼠肠道细菌的原位靶向碱基编辑

Andreas K Brödel #, Loïc H Charpenay #, Matthieu Galtier, Fabien J Fuche, Rémi Terrasse, Chloé Poquet, Jan Havránek, Simone Pignotti, Antonina Krawczyk, Marion Arraou, Gautier Prevot, Dalila Spadoni, Matthew T N Yarnall, Edith M Hessel, Jesus Fernandez-Rodriguez, Xavier Duportet, David Bikard

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

流感诱导的单核细胞来源的肺泡巨噬细胞可提供持久的抗菌保护

Helena Aegerter ,Justina Kulikauskaite ,Stefania Crotta ,Harshil Patel ,Gavin Kelly ,Edith M Hessel ,Matthias Mack ,Soren Beinke ,Andreas Wack

Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages

校正的超分辨率显微镜可实现自发荧光肺巨噬细胞的纳米级成像

Ashley R Ambrose, Susanne Dechantsreiter, Rajesh Shah, M Angeles Montero, Anne Marie Quinn, Edith M Hessel, Soren Beinke, Gillian M Tannahill, Daniel M Davis

Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage

TLR9 和 PI3Kgamma 信号的融合会诱发无菌性炎症和器官损伤

Braulio Henrique Freire Lima, Pedro Elias Marques, Lindisley Ferreira Gomides, Matheus Silvério Mattos, Lucas Kraemer, Celso M Queiroz-Junior, Mark Lennon, Emilio Hirsch, Remo Castro Russo, Gustavo Batista Menezes, Edith M Hessel, Augustin Amour, Mauro Martins Teixeira

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

PI3Kδ 过度激活促进 B 细胞发育,从而以不依赖抗体的方式加剧肺炎链球菌感染。

Anne-Katrien Stark ,Anita Chandra ,Krishnendu Chakraborty ,Rafeah Alam ,Valentina Carbonaro ,Jonathan Clark ,Srividya Sriskantharajah ,Glyn Bradley ,Alex G Richter ,Edward Banham-Hall ,Menna R Clatworthy ,Sergey Nejentsev ,J Nicole Hamblin ,Edith M Hessel ,Alison M Condliffe ,Klaus Okkenhaug

The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages

重复刺激 Toll 样受体 2 和 4 对 COPD 肺泡巨噬细胞的影响

Simon R Lea #, Sophie L Reynolds #, Manminder Kaur, Karen D Simpson, Simon R Hall, Edith M Hessel, Dave Singh

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

急性呼吸窘迫综合征中性粒细胞具有独特的表型,并且对磷酸肌醇 3-激酶抑制具有抗性

Jatinder K Juss, David House, Augustin Amour, Malcolm Begg, Jurgen Herre, Daniel M L Storisteanu, Kim Hoenderdos, Glyn Bradley, Mark Lennon, Charlotte Summers, Edith M Hessel, Alison Condliffe, Edwin R Chilvers

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment

IFNλ 是一种有效的抗流感治疗药物,且没有 IFNα 治疗的炎症副作用

Sophia Davidson, Teresa M McCabe, Stefania Crotta, Hans Henrik Gad, Edith M Hessel, Soren Beinke, Rune Hartmann, Andreas Wack

CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans

含有 CpG 的免疫刺激 DNA 序列在啮齿动物中引起 TNF-alpha 依赖性毒性,但在人类中不引起

John D Campbell, Yan Cho, Martyn L Foster, Holger Kanzler, Melissa A Kachura, Jeremy A Lum, Marianne J Ratcliffe, Atul Sathe, Andrew J Leishman, Ash Bahl, Mark McHale, Robert L Coffman, Edith M Hessel