日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

通过对 MET 受体酪氨酸激酶结构域进行深度突变扫描,揭示了近膜结构域和激酶 N 叶中保守的调控基序

Gabriella O Estevam, Edmond M Linossi, Christian B Macdonald, Carla A Espinoza, Jennifer M Michaud, Willow Coyote-Maestas, Eric A Collisson, Natalia Jura, James S Fraser

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

通过深度突变扫描绘制 MET 受体酪氨酸激酶的激酶结构域抗性机制

Gabriella O Estevam, Edmond M Linossi, Jingyou Rao, Christian B Macdonald, Ashraya Ravikumar, Karson M Chrispens, John A Capra, Willow Coyote-Maestas, Harold Pimentel, Eric A Collisson, Natalia Jura, James S Fraser

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

在 SOCS2-SH2 结构域上发现一个外部位点,可增强 SH2 与磷酸化配体的结合

Edmond M Linossi #, Kunlun Li #, Gianluca Veggiani #, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J Calleja, Narelle Keating, Rebecca Feltham, Andrew J Brooks, Shawn S Li, Sachdev S Sidhu, Jeffrey J Babon, Nadia J Kershaw, Sandra E Nicholson

A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics

对激酶组药典的调查揭示了开发新型驱虫药的多种支架和靶点

Jessica Knox, Nicolas Joly, Edmond M Linossi, José A Carmona-Negrón, Natalia Jura, Lionel Pintard, William Zuercher, Peter J Roy

Identification of a second binding site on the TRIM25 B30.2 domain

识别 TRIM25 B30.2 结构域上的第二个结合位点

Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters, Michael D W Griffin, Michaela U Gack, James M Murphy, Nicos A Nicola, Jeffrey J Babon, Sandra E Nicholson

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

细胞因子信号抑制因子 (SOCS)5 通过抑制 EGFR 信号改善流感感染

Lukasz Kedzierski, Michelle D Tate, Alan C Hsu, Tatiana B Kolesnik, Edmond M Linossi, Laura Dagley, Zhaoguang Dong, Sarah Freeman, Giuseppe Infusini, Malcolm R Starkey, Nicola L Bird, Simon M Chatfield, Jeffrey J Babon, Nicholas Huntington, Gabrielle Belz, Andrew Webb, Peter Ab Wark, Nicos A Nicola,

Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection

细胞因子信号抑制因子 4 (SOCS4) 可预防严重的细胞因子风暴并增强流感感染期间的病毒清除

Lukasz Kedzierski, Edmond M Linossi, Tatiana B Kolesnik, E Bridie Day, Nicola L Bird, Benjamin T Kile, Gabrielle T Belz, Donald Metcalf, Nicos A Nicola, Katherine Kedzierska, Sandra E Nicholson