日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single molecule visualization of tropomyosin isoform organization in the mammalian actin cytoskeleton

哺乳动物肌动蛋白细胞骨架中原肌球蛋白亚型组织的单分子可视化

Maria L Cagigas, Nicholas Ariotti, Jeff Hook, James Rae, Robert G Parton, Nicole S Bryce, Peter W Gunning, Edna C Hardeman

Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer

原肌球蛋白1亚型是高级别浆液性卵巢癌上皮间质可塑性、转移扩散和化疗耐药的基础

Tong Xu ,Mathijs P Verhagen ,Miriam Teeuwssen ,Wenjie Sun ,Rosalie Joosten ,Andrea Sacchetti ,Patricia C Ewing-Graham ,Maurice P H M Jansen ,Ingrid A Boere ,Nicole S Bryce ,Jun Zeng ,Herbert R Treutlein ,Jeff Hook ,Edna C Hardeman ,Peter W Gunning ,Riccardo Fodde

Preexisting tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia

粘附连接处预先存在的组织机械高压会破坏上皮细胞的凋亡挤压

Zoya Mann, Fayth Lim, Suzie Verma, Bageshri N Nanavati, Julie M Davies, Jakob Begun, Edna C Hardeman, Peter W Gunning, Deepa Subramanyam, Alpha S Yap, Kinga Duszyc

Different Mouse Models of Nemaline Myopathy Harboring Acta1 Mutations Display Differing Abnormalities Related to Mitochondrial Biology

携带 Acta1 突变的线粒体肌病不同小鼠模型表现出与线粒体生物学相关的不同异常

Jennifer A Tinklenberg, Rebecca A Slick, Jessica Sutton, Liwen Zhang, Hui Meng, Margaret J Beatka, Mark Vanden Avond, Mariah J Prom, Emily Ott, Federica Montanaro, James Heisner, Rafael Toro, Edna C Hardeman, Aron M Geurts, David F Stowe, R Blake Hill, Michael W Lawlor

Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents

针对上皮性卵巢癌中的肌动蛋白/原肌球蛋白细胞骨架揭示了与抗微管药物协同的多种机制

Xing Xu, Yao Wang, Nicole S Bryce, Katrina Tang, Nicola S Meagher, Eun Young Kang, Linda E Kelemen, Martin Köbel, Susan J Ramus, Michael Friedlander, Caroline E Ford, Edna C Hardeman, Peter W Gunning

A robust method for particulate detection of a genetic tag for 3D electron microscopy

一种用于 3D 电子显微镜的遗传标签颗粒检测的稳健方法

James Rae, Charles Ferguson, Nicholas Ariotti, Richard I Webb, Han-Hao Cheng, James L Mead, James D Riches, Dominic Jb Hunter, Nick Martel, Joanne Baltos, Arthur Christopoulos, Nicole S Bryce, Maria Lastra Cagigas, Sachini Fonseka, Marcel E Sayre, Edna C Hardeman, Peter W Gunning, Yann Gambin, Thoma

Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects

针对肌动蛋白细胞骨架的药物通过消除肌动蛋白介导的纺锤体缺陷修复增强了低剂量长春新碱的细胞毒性

Yao Wang, Jeffrey H Stear, Ashleigh Swain, Xing Xu, Nicole S Bryce, Michael Carnell, Irina B Alieva, Vera B Dugina, Timothy P Cripe, Justine Stehn, Edna C Hardeman, Peter W Gunning

Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1

抗原肌球蛋白化合物 ATM-3507 分子整合到癌症相关 Tpm3.1 的卷曲螺旋重叠区域中

Miro Janco, Michael J Rynkiewicz, Liang Li, Jeff Hook, Eleanor Eiffe, Anita Ghosh, Till Böcking, William J Lehman, Edna C Hardeman, Peter W Gunning

Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments

原肌球蛋白浓度而非成核剂 mDia1 和 mDia3 决定原肌球蛋白掺入肌动蛋白丝的水平

Joyce C M Meiring, Nicole S Bryce, Jorge Luis Galeano Niño, Antje Gabriel, Szun S Tay, Edna C Hardeman, Maté Biro, Peter W Gunning

Developmental Profiling of Tropomyosin Expression in Mouse Brain Reveals Tpm4.2 as the Major Post-synaptic Tropomyosin in the Mature Brain

小鼠大脑中原肌球蛋白表达的发育分析表明 Tpm4.2 是成熟大脑中的主要突触后原肌球蛋白

Alexandra K Suchowerska, Sandra Fok, Holly Stefen, Peter W Gunning, Edna C Hardeman, John Power, Thomas Fath