日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Glucagon Receptor Deficiency Causes Early-Onset Hepatic Steatosis

胰高血糖素受体缺乏导致早发性肝脂肪变性

Tessa M Cacciottolo ,Katherine Lawler ,Kevin M Méndez-Acevedo ,Edson Mendes de Oliveira ,Adam Syanda ,Elana Henning ,Julia M Keogh ,Rebecca Bounds ,Miriam Smith ,Daniyal Ashraf ,David Harman ,Adam Duckworth ,Edmund M Godfrey ,Laura Watson ,Matthew Hoare ,Ben Jones ,Alastair Baker ,Tamir Rashid ,I Sadaf Farooqi

Loss of transient receptor potential channel 5 causes obesity and postpartum depression

瞬时受体电位通道5的缺失会导致肥胖和产后抑郁症。

Yongxiang Li ,Tessa M Cacciottolo ,Na Yin ,Yang He ,Hesong Liu ,Hailan Liu ,Yuxue Yang ,Elana Henning ,Julia M Keogh ,Katherine Lawler ,Edson Mendes de Oliveira ,Eugene J Gardner ,Katherine A Kentistou ,Panayiotis Laouris ,Rebecca Bounds ,Ken K Ong ,John R B Perry ,Inês Barroso ,Longlong Tu ,Jonathan C Bean ,Meng Yu ,Kristine M Conde ,Mengjie Wang ,Olivia Ginnard ,Xing Fang ,Lydia Tong ,Junying Han ,Tia Darwich ,Kevin W Williams ,Yongjie Yang ,Chunmei Wang ,Shelagh Joss ,Helen V Firth ,Yong Xu ,I Sadaf Farooqi

A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies

评估人类瘦素编码变体分泌的定量流程揭示了瘦素缺乏的潜在机制

Harry J M Baird, Amber S Shun-Shion, Edson Mendes de Oliveira, Danièle Stalder, Lu Liang, Jessica Eden, Joseph E Chambers, I Sadaf Farooqi, David C Gershlick, Daniel J Fazakerley

A rare human variant that disrupts GPR10 signalling causes weight gain in mice

一种破坏 GPR10 信号传导的罕见人类变异导致小鼠体重增加

Fleur Talbot #, Claire H Feetham #, Jacek Mokrosiński #, Katherine Lawler, Julia M Keogh, Elana Henning, Edson Mendes de Oliveira, Vikram Ayinampudi, Sadia Saeed, Amélie Bonnefond, Mohammed Arslan, Giles S H Yeo, Philippe Froguel, David A Bechtold, Antony Adamson, Neil Humphreys, Inês Barroso, Simon

Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior

人类血清素 2C 受体功能丧失变异与肥胖和适应不良行为有关

Yang He #, Bas Brouwers #, Hesong Liu #, Hailan Liu, Katherine Lawler, Edson Mendes de Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R Cox, Julia M Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A Sc

Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance

急性炎症是体重增加和胰岛素抵抗的诱因

Edson Mendes de Oliveira, Jacqueline C Silva, Thais P Ascar, Silvana Sandri, Alexandre F Marchi, Silene Migliorini, Helder T I Nakaya, Ricardo A Fock, Ana Campa

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

人类MC4R变异体影响内吞作用、转运和二聚化,揭示了参与体重调节的多种细胞机制。

Bas Brouwers ,Edson Mendes de Oliveira ,Maria Marti-Solano ,Fabiola B F Monteiro ,Suli-Anne Laurin ,Julia M Keogh ,Elana Henning ,Rebecca Bounds ,Carole A Daly ,Shane Houston ,Vikram Ayinampudi ,Natalia Wasiluk ,David Clarke ,Bianca Plouffe ,Michel Bouvier ,M Madan Babu ,I Sadaf Farooqi ,Jacek Mokrosiński

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance

人类信号素3变体与黑皮质素回路发育和能量平衡相关

Agatha A van der Klaauw ,Sophie Croizier ,Edson Mendes de Oliveira ,Lukas K J Stadler ,Soyoung Park ,Youxin Kong ,Matthew C Banton ,Panna Tandon ,Audrey E Hendricks ,Julia M Keogh ,Susanna E Riley ,Sofia Papadia ,Elana Henning ,Rebecca Bounds ,Elena G Bochukova ,Vanisha Mistry ,Stephen O'Rahilly ,Richard B Simerly ,Inês Barroso ,E Yvonne Jones ,Sebastien G Bouret ,I Sadaf Farooqi

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

人类MC4R功能获得性变异体表现出信号传导偏向性并能预防肥胖

Luca A Lotta ,Jacek Mokrosiński ,Edson Mendes de Oliveira ,Chen Li ,Stephen J Sharp ,Jian'an Luan ,Bas Brouwers ,Vikram Ayinampudi ,Nicholas Bowker ,Nicola Kerrison ,Vasileios Kaimakis ,Diana Hoult ,Isobel D Stewart ,Eleanor Wheeler ,Felix R Day ,John R B Perry ,Claudia Langenberg ,Nicholas J Wareham ,I Sadaf Farooqi

Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance

SH2B1 PH 结构域对能量平衡控制的关键作用

Anabel Flores, Lawrence S Argetsinger, Lukas K J Stadler, Alvaro E Malaga, Paul B Vander, Lauren C DeSantis, Ray M Joe, Joel M Cline, Julia M Keogh, Elana Henning, Ines Barroso, Edson Mendes de Oliveira, Gowri Chandrashekar, Erik S Clutter, Yixin Hu, Jeanne Stuckey, I Sadaf Farooqi, Martin G Myers J