日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade

将 RAS(ON) G12C 选择性抑制剂与 SHP2 抑制剂相结合可增强肺癌对免疫检查点阻断的敏感性

Panayiotis Anastasiou, Christopher Moore, Sareena Rana, Mona Tomaschko, Claire E Pillsbury, Andrea de Castro, Jesse Boumelha, Edurne Mugarza, Sophie de Carné Trécesson, Ania Mikolajczak, Cristina Blaj, Robert Goldstone, Jacqueline A M Smith, Elsa Quintana, Miriam Molina-Arcas, Julian Downward

CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes

靶向TYRP1表面表达的CAR-T细胞疗法用于治疗皮肤黑色素瘤和罕见黑色素瘤亚型

Sameeha Jilani # ,Justin D Saco # ,Edurne Mugarza # ,Aleida Pujol-Morcillo ,Jeffrey Chokry ,Clement Ng ,Gabriel Abril-Rodriguez ,David Berger-Manerio ,Ami Pant ,Jane Hu ,Rubi Gupta ,Agustin Vega-Crespo ,Ignacio Baselga-Carretero ,Jia M Chen ,Daniel Sanghoon Shin ,Philip Scumpia ,Roxana A Radu ,Yvonne Chen ,Antoni Ribas ,Cristina Puig-Saus

CRISPR-Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

CRISPR-Cas9 筛查确定 KRAS 诱导的 COX2 是肺癌免疫疗法耐药性的驱动因素

Jesse Boumelha, Andrea de Castro, Nourdine Bah, Hongui Cha, Sophie de Carné Trécesson, Sareena Rana, Mona Tomaschko, Panayiotis Anastasiou, Edurne Mugarza, Christopher Moore, Robert Goldstone, Phil East, Kevin Litchfield, Se-Hoon Lee, Miriam Molina-Arcas, Julian Downward

An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations

KRAS 突变型肺癌的免疫原性模型可用于评估靶向治疗和免疫治疗组合

Jesse Boumelha #, Sophie de Carné Trécesson #, Emily K Law #, Pablo Romero-Clavijo, Matthew A Coelho, Kevin W Ng, Edurne Mugarza, Christopher Moore, Sareena Rana, Deborah R Caswell, Miguel Murillo, David C Hancock, Prokopios P Argyris, William L Brown, Cameron Durfee, Lindsay K Larson, Rachel I Voge

Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers

治疗性KRASG12C抑制可有效驱动免疫原性肺癌中的干扰素介导的抗肿瘤免疫

Edurne Mugarza ,Febe van Maldegem ,Jesse Boumelha ,Christopher Moore ,Sareena Rana ,Miriam Llorian Sopena ,Philip East ,Rachel Ambler ,Panayiotis Anastasiou ,Pablo Romero-Clavijo ,Karishma Valand ,Megan Cole ,Miriam Molina-Arcas ,Julian Downward