日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses

针对 SARS-CoV-2 的模块化无佐剂泛 HLA-DR 免疫靶向亚单位疫苗可引发广泛的 sarbecovirus 中和抗体反应

Audrey Kassardjian, Eric Sun, Jamie Sookhoo, Krithika Muthuraman, Kayluz Frias Boligan, Iga Kucharska, Edurne Rujas, Arif Jetha, Donald R Branch, Shawn Babiuk, Brian Barber, Jean-Philippe Julien

Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope

膜锚定 HIV-1 泛中和表位的分子识别

Johana Torralba, Igor de la Arada, Angélica Partida-Hanon, Edurne Rujas, Madalen Arribas, Sara Insausti, Claire Valotteau, Javier Valle, David Andreu, José M M Caaveiro, María Angeles Jiménez, Beatriz Apellániz, Lorena Redondo-Morata, José L Nieva3

Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells

双重抑制液泡ATPase和TMPRSS2是完全阻断SARS-CoV-2进入细胞所必需的

Simoun Icho ,Edurne Rujas ,Krithika Muthuraman ,John Tam ,Huazhu Liang ,Shelby Landreth ,Mingmin Liao ,Darryl Falzarano ,Jean-Philippe Julien ,Roman A Melnyk

Functional Delineation of a Protein-Membrane Interaction Hotspot Site on the HIV-1 Neutralizing Antibody 10E8

HIV-1中和抗体10E8上蛋白质-膜相互作用热点位点的功能界定

Sara Insausti,Miguel Garcia-Porras,Johana Torralba,Izaskun Morillo,Ander Ramos-Caballero,Igor de la Arada,Beatriz Apellaniz,Jose M M Caaveiro,Pablo Carravilla,Christian Eggeling,Edurne Rujas,Jose L Nieva

Engineering pan-HIV-1 neutralization potency through multispecific antibody avidity

通过多特异性抗体亲和力设计泛 HIV-1 中和效力

Edurne Rujas, Hong Cui, Jonathan Burnie, Clare Burn Aschner, Tiantian Zhao, Sara Insausti, Krithika Muthuraman, Anthony Semesi, Jasper Ophel, Jose L Nieva, Michael S Seaman, Christina Guzzo, Bebhinn Treanor, Jean-Philippe Julien

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

多价性将 SARS-CoV-2 抗体转化为超强中和剂

Edurne Rujas, Iga Kucharska, Yong Zi Tan, Samir Benlekbir, Hong Cui, Tiantian Zhao, Gregory A Wasney, Patrick Budylowski, Furkan Guvenc, Jocelyn C Newton, Taylor Sicard, Anthony Semesi, Krithika Muthuraman, Amy Nouanesengsy, Clare Burn Aschner, Katherine Prieto, Stephanie A Bueler, Sawsan Youssef, S

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

冻干、耐热 Spike 或 RBD 免疫原性脂质体可在小鼠中诱导针对 SARS-CoV-2 的保护性免疫

Moustafa T Mabrouk, Kevin Chiem, Edurne Rujas, Wei-Chiao Huang, Dushyant Jahagirdar, Breandan Quinn, Meera Surendran Nair, Ruth H Nissly, Victoria S Cavener, Nina R Boyle, Ty A Sornberger, Suresh V Kuchipudi, Joaquin Ortega, Jean-Philippe Julien, Luis Martinez-Sobrido, Jonathan Lovell

Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile

CDRH3 环路处的芳香性局部积累可减轻 4E10 的多反应性,而不会改变其 HIV 中和特性

Edurne Rujas, Daniel P Leaman, Sara Insausti, Pablo Carravilla, Miguel García-Porras, Eneko Largo, Izaskun Morillo, Rubén Sánchez-Eugenia, Lei Zhang, Hong Cui, Ibon Iloro, Félix Elortza, Jean-Philippe Julien, Christian Eggeling, Michael B Zwick, Jose M M Caaveiro, José L Nieva

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

多尺度相互作用组分析结合脱靶药物预测揭示了可用于治疗人类冠状病毒疾病的药物再利用候选药物。

Michael G Sugiyama # ,Haotian Cui # ,Dar'ya S Redka # ,Mehran Karimzadeh ,Edurne Rujas ,Hassaan Maan ,Sikander Hayat ,Kyle Cheung ,Rahul Misra ,Joseph B McPhee ,Russell D Viirre ,Andrew Haller ,Roberto J Botelho ,Raffi Karshafian ,Sarah A Sabatinos ,Gregory D Fairn ,Seyed Ali Madani Tonekaboni ,Andreas Windemuth ,Jean-Philippe Julien ,Vijay Shahani ,Stephen S MacKinnon ,Bo Wang ,Costin N Antonescu

Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments

界面亲和力决定了抗体在膜环境中的效力

Edurne Rujas, Sara Insausti, Daniel P Leaman, Pablo Carravilla, Saul González-Resines, Valérie Monceaux, Rubén Sánchez-Eugenia, Miguel García-Porras, Ibon Iloro, Lei Zhang, Félix Elortza, Jean-Philippe Julien, Asier Saéz-Cirión, Michael B Zwick, Christian Eggeling, Akio Ojida, Carmen Domene, Jose M