日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Drug-Inducible Gene Therapy Effectively Reduces Spontaneous Seizures in Kindled Rats but Creates Off-Target Side Effects in Inhibitory Neurons

药物诱导基因疗法可有效减少点燃大鼠的自发性癫痫发作,但在抑制神经元中产生脱靶副作用

Kyle A Sullivan, Iuliia Vitko, Kathryn Blair, Ronald P Gaykema, Madison J Failor, Jennifer M San Pietro, Deblina Dey, John M Williamson, Ruth L Stornetta, Jaideep Kapur, Edward Perez-Reyes

EpiPro, a Novel, Synthetic, Activity-Regulated Promoter That Targets Hyperactive Neurons in Epilepsy for Gene Therapy Applications

EpiPro 是一种新型合成活性调节启动子,可靶向治疗癫痫中的过度活跃神经元,用于基因治疗应用

Cassidy T Burke, Iuliia Vitko, Justyna Straub, Elsa O Nylund, Agnieszka Gawda, Kathryn Blair, Kyle A Sullivan, Lara Ergun, Matteo Ottolini, Manoj K Patel, Edward Perez-Reyes

Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis

在已确诊肝脂肪变性的小鼠中,通过基于腺相关病毒(AAV)的基因疗法靶向氧化磷脂可阻止其发展为纤维化。

Clint M Upchurch ,Scott Yeudall ,Caitlin M Pavelec ,Dennis Merk ,Jan Greulich ,Mohan Manjegowda ,Shyam S Raghavan ,Irina M Bochkis ,Michael M Scott ,Edward Perez-Reyes ,Norbert Leitinger

AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures

AMPK 介导的 GABA 信号增强可导致低血糖诱发的棘波癫痫

Kathryn A Salvati, Matthew L Ritger, Pasha A Davoudian, Finnegan O'Dell, Daniel R Wyskiel, George M P R Souza, Adam C Lu, Edward Perez-Reyes, Joshua C Drake, Zhen Yan, Mark P Beenhakker

A brainstem peptide system activated at birth protects postnatal breathing

出生时激活的脑干肽系统保护出生后的呼吸

Yingtang Shi, Daniel S Stornetta, Robert J Reklow, Alisha Sahu, Yvonne Wabara, Ashley Nguyen, Keyong Li, Yong Zhang, Edward Perez-Reyes, Rachel A Ross, Bradford B Lowell, Ruth L Stornetta, Gregory D Funk, Patrice G Guyenet, Douglas A Bayliss

Characterization of kindled VGAT-Cre mice as a new animal model of temporal lobe epilepsy

点燃 VGAT-Cre 小鼠作为颞叶癫痫新动物模型的表征

Justyna Straub, Agnieszka Gawda, Pranav Ravichandran, Bailey McGrew, Elsa Nylund, Julianna Kang, Cassidy Burke, Iuliia Vitko, Michael Scott, John Williamson, Suchitra Joshi, Jaideep Kapur, Edward Perez-Reyes

LMO7 deficiency reveals the significance of the cuticular plate for hearing function

LMO7 缺乏揭示了角质板对听觉功能的重要性

Ting-Ting Du, James B Dewey, Elizabeth L Wagner, Runjia Cui, Jinho Heo, Jeong-Jin Park, Shimon P Francis, Edward Perez-Reyes, Stacey J Guillot, Nicholas E Sherman, Wenhao Xu, John S Oghalai, Bechara Kachar, Jung-Bum Shin

Inhibition of T-Type calcium channels in mEC layer II stellate neurons reduces neuronal hyperexcitability associated with epilepsy

抑制 mEC II 层星状神经元中的 T 型钙通道可降低与癫痫相关的神经元兴奋性

Aradhya Nigam, Nicholas J Hargus, Bryan S Barker, Matteo Ottolini, James A Hounshell, Edward H Bertram 3rd, Edward Perez-Reyes, Manoj K Patel

CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity

CACHD1 是一种 α2δ 样蛋白,可调节 CaV3 电压门控钙通道活性

Graeme S Cottrell, Camille H Soubrane, James A Hounshell, Hong Lin, Venetia Owenson, Michael Rigby, Peter J Cox, Bryan S Barker, Matteo Ottolini, Selvi Ince, Claudia C Bauer, Edward Perez-Reyes, Manoj K Patel, Edward B Stevens, Gary J Stephens

Calmodulin regulates Cav3 T-type channels at their gating brake

钙调蛋白调节 Cav3 T 型通道的门控制动器

Jean Chemin, Valentina Taiakina, Arnaud Monteil, Michael Piazza, Wendy Guan, Robert F Stephens, Ashraf Kitmitto, Zhiping P Pang, Annette C Dolphin, Edward Perez-Reyes, Thorsten Dieckmann, Joseph Guy Guillemette, J David Spafford