日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A polygenetic rat model of divergent aerobic capacity reveals a liver-brain interaction impacting Alzheimer's disease-like phenotypes

具有不同有氧能力的多基因大鼠模型揭示了肝脑相互作用对阿尔茨海默病样表型的影响

Lysaker, Colton R; Kugler, Benjamin A; Csikos, Vivien; Birky, Cole J; Gilmore, Caleb A; Wenger, Madi; Franczak, Edziu; Davis, Xin; Hauger, Brittany M; Allen, Julie A; Troutwine, Benjamin R; Gonzalez-Duran, Laura; McCoin, Colin S; Chauhan, Munish; Harris, Janna L; Frazier, Alexandria L; Winter, Michelle K; Koch, Lauren G; Britton, Steven L; Thyfault, John P; Wilkins, Heather M

Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration

线粒体DNA突变的积累与NADH依赖性呼吸作用的特定缺陷有关

Franczak, Edziu; Montgomery, McLane M; Terwilliger, Zoe S; Aruleba, Raphael T; Krassovskaia, Polina; Boykov, Ilya N; Hagen, James T; Pacheco, Emely A; Chrest, Brett R; Zeczycki, Tonya N; Vandiver, Kayla J; Neufer, P Darrell; McClung, Joseph M; Fisher-Wellman, Kelsey H

APOE4 drives widespread changes to the hepatic proteome and alters metabolic function.

APOE4 驱动肝脏蛋白质组发生广泛变化,并改变代谢功能。

Lysaker Colton R, Johnson Chelsea N, Csikos Vivien, Franczak Edziu, Tetlow Ashley L, Benson Maggie, Thyfault John P, Geiger Paige C, Morris Jill K, Wilkins Heather M

APOE4 Exerts Partial Diet-dependent Effects on Energy Expenditure and Skeletal Muscle Mitochondrial Pathways in a Preclinical Model.

在临床前模型中,APOE4 对能量消耗和骨骼肌线粒体通路产生部分饮食依赖性影响

Johnson Chelsea N, Lysaker Colton R, Gast Elaine C, McCoin Colin S, Kemna Riley E, Fuller Kelly N Z, Kugler Benjamin A, Franczak Edziu, Csikos Vivien, Allen Julie, John Casey S, Wolf MaryJane A, Morris Matthew E, Thyfault John P, Wilkins Heather M, Geiger Paige C, Morris Jill K

Donepezil treatment, alone or combined with exercise, enhances skeletal muscle function in healthy and advanced aging disease mouse models.

多奈哌齐治疗,无论是单独使用还是与运动结合使用,都能增强健康和衰老疾病小鼠模型的骨骼肌功能。

Ernst Nicholas J, Franczak Edziu, Allen Julie, Minchew Everett C, Readyoff Andrew T, Farlow Miles C, Spangenburg Espen E, Miller Benjamin F, Morris Jill K, Shankar Kartik, Sardiu Mihaela E, Zhu Hao, Stanford John A, Thyfault John P, McCoin Colin S

Loss of ovarian function prevents exercise-induced activation of hepatic mitophagic flux.

卵巢功能丧失会阻止运动诱导的肝脏线粒体自噬通量的激活

Franczak Edziu, Kugler Benjamin A, Salathe Sebastian F, Allen Julie A, Sardiu Mihaela E, McCoin Colin S, Hevener Andrea L, Morris E Matthew, Thyfault John P

Loss of ovarian function and estrogen therapy remodel the brain's synaptic and metabolic proteome

卵巢功能丧失和雌激素疗法会重塑大脑的突触和代谢蛋白质组。

Salathe, Sebastian F; Franczak, Edziu; Busick, Zane; Boakye, Frederick B; Allen, Julie; Lutkewitte, Andrew; Wilkins, Heather; John, Thyfault; Kugler, Benjamin A

Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice

脂肪组织中烟酰胺磷酸核糖转移酶的过表达可预防肥胖小鼠的代谢功能障碍

Ferguson, Daniel; Gadson, Elise I; Markan, Kathleen R; Yoshino, Jun; Lin, Maxwell; Habibi, Mohammad; Tiash, Snigdha; Cui, Xiaoxia; Kouranova, Evguenia; Franczak, Edziu; Guo, Qiuyuan; Kealing, Jill; Pietka, Terri A; Liss, Kim H H; Thyfault, John P; Patti, Gary J; Finck, Brian N; Crewe, Clair; Mukherjee, Sandip

Endurance exercise drives temporal and sexual dimorphic multi-omic adaptations in liver metabolism-Findings from MoTrPAC

耐力运动驱动肝脏代谢中时间和性别二态性的多组学适应——来自MoTrPAC的研究结果

Kelty, Taylor J; Franczak, Edziu; Gay, Nicole R; Many, Gina M; Sagendorf, Tyler J; Sanford, James A; Hou, Zhenxin; Gaul, David A; Fernández, Facundo M; Burant, Charles; Hevener, Andrea L; Adkins, Joshua N; Bodine, Sue; Lindholm, Malene E; Ortlund, Eric A; Schenk, Simon; Thyfault, John P; Rector, R Scott

Chemical-induced colitis lowers mitochondrial bioenergetic function in the colonic epithelium with minimal impacts on the proteome

化学诱导的结肠炎会降低结肠上皮细胞线粒体的生物能量功能,而对蛋白质组的影响甚微。

Montgomery, McLane M; Al Obaidi, Masara A; Aruleba, Raphael T; Krassovskaia, Polina; Pacheco, Emely A; Franczak, Edziu; Chrest, Brett R; Green, Thomas D; Zeczycki, Tonya N; McClung, Joeseph M; Fisher-Wellman, Kelsey H