日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5-week study in A/J mice

香烟烟雾和香精混合物气溶胶吸入毒性评估:对 A/J 小鼠进行为期 5 周的研究

Ee Tsin Wong, Karsta Luettich, Lydia Cammack, Chin Suan Chua, David Sciuscio, Celine Merg, Maica Corciulo, Romain Piault, Kumar Ashutosh, Cameron Smith, Patrice Leroy, Fabian Moine, Anneke Glabasnia, Pierrick Diana, Cecilia Chia, Ching Keong Tung, Nikolai Ivanov, Julia Hoeng, Manuel Peitsch, Kyeongh

A 6-month inhalation toxicology study in Apoe-/- mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract

一项针对 Apoe-/- 小鼠的为期 6 个月的吸入毒理学研究表明,与香烟烟雾相比,电子蒸汽气溶胶对呼吸道的影响明显较低

Ee Tsin Wong #, Justyna Szostak #, Bjoern Titz, Tom Lee, Sin Kei Wong, Oksana Lavrynenko, Celine Merg, Maica Corciulo, Jovan Simicevic, Mehdi Auberson, Dariusz Peric, Remi Dulize, David Bornand, Guo Jie Loh, Kyeonghee Monica Lee, Jingjie Zhang, John H Miller 4th, Walter K Schlage, Emmanuel Guedj, Th

Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data

利用基因表达和突变谱数据区分 A/J 小鼠自发性增生性肺病变与香烟烟雾和 THS 2.2 气溶胶暴露相关增生性肺病变

Yang Xiang, Karsta Luettich, Florian Martin, James N D Battey, Keyur Trivedi, Laurent Neau, Ee Tsin Wong, Emmanuel Guedj, Remi Dulize, Dariusz Peric, David Bornand, Sonia Ouadi, Nicolas Sierro, Ansgar Büttner, Nikolai V Ivanov, Patrick Vanscheeuwijck, Julia Hoeng, Manuel C Peitsch

Impact of whole-body versus nose-only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE-/- mouse model

在 ApoE-/- 小鼠模型中进行的为期 2 个月的香烟烟雾暴露研究中,全身吸入暴露系统与仅鼻吸入暴露系统对全身、呼吸和心血管终点的影响

Ulrike Kogel, Ee Tsin Wong, Justyna Szostak, Wei Teck Tan, Francesco Lucci, Patrice Leroy, Bjoern Titz, Yang Xiang, Tiffany Low, Sin Kei Wong, Emmanuel Guedj, Nikolai V Ivanov, Walter K Schlage, Manuel C Peitsch, Arkadiusz Kuczaj, Patrick Vanscheeuwijck, Julia Hoeng

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE(-/-) mouse model

在ApoE(-/-)小鼠模型中,吸入电子烟气溶胶6个月后,与香烟烟雾相比,电子烟气溶胶不会损害骨骼完整性。

Reumann, Marie K; Schaefer, Jenny; Titz, Bjoern; Aspera-Werz, Romina H; Wong, Ee Tsin; Szostak, Justyna; Häussling, Victor; Ehnert, Sabrina; Leroy, Patrice; Tan, Wei Teck; Kuczaj, Arkadiusz; Audretsch, Christof; Springer, Fabian; Badke, Andreas; Augat, Peter; Quentanilla-Fend, Leticia; Martella, Manuela; Lee, K Monica; Peitsch, Manuel C; Hoeng, Julia; Nussler, Andreas K

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice

在为期 18 个月的 A/J 小鼠系统毒理学研究中,暴露于候选改良风险烟草产品 THS 2.2 的气溶胶对呼吸系统的影响

Bjoern Titz, Alain Sewer, Karsta Luettich, Ee Tsin Wong, Emmanuel Guedj, Catherine Nury, Thomas Schneider, Yang Xiang, Keyur Trivedi, Grégory Vuillaume, Patrice Leroy, Ansgar Büttner, Florian Martin, Nikolai V Ivanov, Patrick Vanscheeuwijck, Julia Hoeng, Manuel C Peitsch

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke

与香烟烟雾相比,A/J 小鼠终生接触加热烟草制品气溶胶可降低其慢性毒性和致癌性

Ee Tsin Wong, Karsta Luettich, Subash Krishnan, Sin Kei Wong, Wei Ting Lim, Demetrius Yeo, Ansgar Büttner, Patrice Leroy, Grégory Vuillaume, Stéphanie Boué, Julia Hoeng, Patrick Vanscheeuwijck, Manuel C Peitsch

Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case

比较吸入式候选产品和潜在候选改良风险烟草产品的临床前风险特征:一个过渡性用例

Schlage, Walter K; Titz, Bjoern; Iskandar, Anita; Poussin, Carine; Van der Toorn, Marco; Wong, Ee Tsin; Pratte, Pascal; Maeder, Serge; Schaller, Jean-Pierre; Pospisil, Pavel; Boue, Stephanie; Vuillaume, Grégory; Leroy, Patrice; Martin, Florian; Ivanov, Nikolai V; Peitsch, Manuel C; Hoeng, Julia

A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time

一个多功能平台,可实时分析活细胞中低亲和力和瞬时蛋白质-蛋白质相互作用

Yao-Cheng Li, Luo Wei Rodewald, Christian Hoppmann, Ee Tsin Wong, Sylvain Lebreton, Pavel Safar, Marcel Patek, Lei Wang, Kenneth F Wertman, Geoffrey M Wahl

ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress

ATM和NEMO依赖的ELKS泛素化协调TAK1介导的IKK激活,以响应基因毒性应激。

Wu, Zhao-Hui; Wong, Ee Tsin; Shi, Yuling; Niu, Jixiao; Chen, Zhijian; Miyamoto, Shigeki; Tergaonkar, Vinay