Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration.
降低单链单价 BBB 穿梭分子 scFc-scFv8D3 的亲和力可延长其半衰期并提高其在大脑中的浓度
期刊:Neurotherapeutics
影响因子:6.9
doi:10.1016/j.neurot.2024.e00492
Rosa Andrés de la, Metzendorf Nicole G, Efverström Jonathan, Godec Ana, Sehlin Dag, Morrison Jamie, Hultqvist Greta
