日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators

获得的靶向改变导致对 p53-Y220C 激活剂的临床耐药性

Fece de la Cruz, Ferran; Varkaris, Andreas; Patel, Parasvi S; Kushner, Elijah W; Morales-Giron, Alvin A; Lee, Sangmi Sandra; Singh, Ankit; Kim, Clara T; Norden, Bryanna L; Ehnstrom, Sara; Riedl, Jakob M; Curtis, Jacquelyn M; Barnes, Haley; Kehlmann, Allison M; Chevalier, Nicholas J; Okuma, Hitomi S; Patel, Manisha; Wirth, Lori J; Connell, Brendan; Nugent, Francis; Pappas, Leontios; Lau, Kayao; Juric, Dejan; Hopkins, Jessica L; Guiley, Keelan Z; Shokat, Kevan M; Gulhan, Doga C; Parikh, Aparna R; Corcoran, Ryan B

Genomic landscape of clinically acquired resistance alterations in patients treated with KRAS(G12C) inhibitors

KRAS(G12C)抑制剂治疗患者临床获得性耐药性改变的基因组图谱

Riedl, J M; Fece de la Cruz, F; Lin, J J; Parseghian, C; Kim, J E; Matsubara, H; Barnes, H; Caughey, B; Norden, B L; Morales-Giron, A A; Kushner, E W; Ehnstrom, S; Nakamura, H; Patel, P S; Ellis, H; Pappas, L; Vakaris, A; Gainor, J F; Kopetz, S; Klempner, S J; Parikh, A R; Hata, A N; Heist, R S; Corcoran, R B

An infralimbic cortex engram encoded during learning attenuates fear generalization

学习过程中编码的下边缘皮层记忆痕迹会减弱恐惧泛化

Subramanian, Rajani; Bauman, Avery; Carpenter, Olivia; Cho, Chris; Coste, Gabrielle; Dam, Ahona; Drake, Kasey; Ehnstrom, Sara; Fitzgerald, Naomi; Jenkins, Abigail; Koolpe, Hannah; Liu, Runqi; Paserman, Tamar; Petersen, David; Scala Chavez, Diego; Rozental, Stefano; Thompson, Hannah; Tsukuda, Tyler; Zweig, Sasha; Gall, Megan; Zupan, Bojana; Bergstrom, Hadley

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

变构 PI3Kα 抑制剂可克服由继发性 PIK3CA 突变介导的对正构抑制剂的靶向耐药性

Andreas Varkaris #, Ferran Fece de la Cruz #, Elizabeth E Martin #, Bryanna L Norden, Nicholas Chevalier, Allison M Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P Danysh, Laxmi

Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers

Sotorasib 是一种泛 RASG12C 抑制剂,能够促进 NRASG12C 癌症的临床反应

Douglas A Rubinson #, Noritaka Tanaka #, Ferran Fece de la Cruz, Kevin S Kapner, Michael H Rosenthal, Bryanna L Norden, Haley Barnes, Sara Ehnstrom, Alvin A Morales-Giron, Lauren K Brais, Christopher T Lemke, Andrew J Aguirre, Ryan B Corcoran

An infralimbic cortex neuronal ensemble encoded during learning attenuates fear generalization expression

学习过程中编码的下边缘皮层神经元群会减弱恐惧泛化表达

Subramanian, Rajani; Bauman, Avery; Carpenter, Olivia; Cho, Chris; Coste, Gabrielle; Dam, Ahona; Drake, Kasey; Ehnstrom, Sara; Fitzgerald, Naomi; Jenkins, Abigail; Koolpe, Hannah; Liu, Runqi; Paserman, Tamar; Petersen, David; Chavez, Diego Scala; Rozental, Stefano; Thompson, Hannah; Tsukuda, Tyler; Zweig, Sasha; Gall, Megan; Zupan, Bojana; Bergstrom, Hadley

Adolescence alcohol exposure impairs fear extinction and alters medial prefrontal cortex plasticity

青少年酒精暴露会损害恐惧消退并改变内侧前额叶皮质的可塑性

K Lawson, M J Scarlata, W C Cho, C Mangan, D Petersen, H M Thompson, S Ehnstrom, A L Mousley, J L Bezek, H C Bergstrom

Morning Exercise Reduces Abdominal Fat and Blood Pressure in Women; Evening Exercise Increases Muscular Performance in Women and Lowers Blood Pressure in Men

晨练可减少女性腹部脂肪并降低血压;晚间锻炼可增强女性肌肉力量并降低男性血压。

Arciero, Paul J; Ives, Stephen J; Mohr, Alex E; Robinson, Nathaniel; Escudero, Daniela; Robinson, Jake; Rose, Kayla; Minicucci, Olivia; O'Brien, Gabriel; Curran, Kathryn; Miller, Vincent J; He, Feng; Norton, Chelsea; Paul, Maia; Sheridan, Caitlin; Beard, Sheriden; Centore, Jessica; Dudar, Monique; Ehnstrom, Katy; Hoyte, Dakembay; Mak, Heather; Yarde, Aaliyah