日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A novel C. elegans model for MAPT/Tau spreading reveals genes critical for endolysosomal integrity and seeded MAPT/Tau aggregation.

一种新的秀丽隐杆线虫 MAPT/Tau 扩散模型揭示了对内溶酶体完整性和 MAPT/Tau 聚集种子至关重要的基因。

Sandhof Carl Alexander, Martin Nicole, Tittelmeier Jessica, Schlueter Annabelle, Pezzali Martina, Schoendorf David C, Lange Timo, Reinhardt Peter, Ried Janina S, Liang Siwen, Uzunoglu Gamze, Gasparini Laura, Jahn Thomas R, Ehrnhoefer Dagmar E, Nussbaum-Krammer Carmen

hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation.

hiPSC-神经元重现了亚型特异性细胞内在的易感性,这种易感性与神经退行性疾病相关的聚集有关

Weidling Ian, Preiss Christina N, Chancellor Sarah E, Srivastava Gyan, Gibilisco Lauren, Lin Gen, Brennan Melanie Shackett, Lee Janice, Roth Lindsay M, Morozova Olga, Nam Kyong Nyon, Patel Nehal R, Liu Qing, Thomas J K, Reinhardt Peter, Wilkens Ruven, Ehrnhoefer Dagmar E, Striebinger Andreas, Barghorn Stefan, Xanthopoulos Christina, Weil Marie-Theres, Biesinger Sandra, Cik Miroslav, Romanul Nandini, Yanamandra Kiran, Welker Alessandra M, Wu Jessica, Gasparini Laura, Stöhr Jan, Langlois Xavier, Manos Justine D

Author Correction: Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates

作者更正:完全不含辅因子的ClearTau平台可产生具有成核能力的Tau原纤维,用于重建病理性Tau聚集体。

Limorenko, Galina; Tatli, Meltem; Kolla, Rajasekhar; Nazarov, Sergey; Weil, Marie-Theres; Schöndorf, David C; Geist, Daniela; Reinhardt, Peter; Ehrnhoefer, Dagmar E; Stahlberg, Henning; Gasparini, Laura; Lashuel, Hilal A

Correction: Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain

更正:tau 种子扩增检测揭示了阿尔茨海默病脑组织中 tau 种子与病理形式之间的关系

Frey, Bryan; Holzinger, David; Taylor, Keenan; Ehrnhoefer, Dagmar E; Striebinger, Andreas; Biesinger, Sandra; Gasparini, Laura; O'Neill, Michael J; Wegner, Florian; Barghorn, Stefan; Höglinger, Günter U; Heym, Roland G

Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates

完全无辅助因子的 ClearTau 平台可产生具有播种能力的 Tau 原纤维,用于重建病理性 Tau 聚集体

Galina Limorenko, Meltem Tatli, Rajasekhar Kolla, Sergey Nazarov, Marie-Theres Weil, David C Schöndorf, Daniela Geist, Peter Reinhardt, Dagmar E Ehrnhoefer, Henning Stahlberg, Laura Gasparini, Hilal A Lashuel

Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain

Tau 种子扩增试验揭示阿尔茨海默病大脑中 tau 的种子和病理形式之间的关系

Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J O'Neill, Florian Wegner, Stefan Barghorn, Günter U Höglinger, Roland G Heym

SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease

SETD7 介导的单甲基化在阿尔茨海默病中的可溶性 Tau 上富集

Maria Bichmann, Nuria Prat Oriol, Ebru Ercan-Herbst, David C Schöndorf, Borja Gomez Ramos, Vera Schwärzler, Marie Neu, Annabelle Schlüter, Xue Wang, Liang Jin, Chenqi Hu, Yu Tian, Janina S Ried, Per Haberkant, Laura Gasparini, Dagmar E Ehrnhoefer

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound

突变的亨廷顿蛋白片段可促进 Caspase-6 的激活,而变构抑制剂化合物可阻断该激活

Dagmar E Ehrnhoefer, Niels H Skotte, Jeanette Reinshagen, Xiaofan Qiu, Björn Windshügel, Priyadarshini Jaishankar, Safia Ladha, Olga Petina, Mehdi Khankischpur, Yen T N Nguyen, Nicholas S Caron, Adelia Razeto, Matthias Meyer Zu Rheda, Yu Deng, Khuong T Huynh, Ilka Wittig, Philip Gribbon, Adam R Rens

A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain

翻译后修饰特征定义了可溶性 tau 的变化与早期阿尔茨海默病脑中的寡聚化相关

Ebru Ercan-Herbst, Jens Ehrig, David C Schöndorf, Annika Behrendt, Bernd Klaus, Borja Gomez Ramos, Nuria Prat Oriol, Christian Weber, Dagmar E Ehrnhoefer

Asparagine endopeptidase cleaves tau at N167 after uptake into microglia

天冬酰胺内肽酶在被小胶质细胞吸收后,在 N167 位点裂解 tau

Annika Behrendt, Maria Bichmann, Ebru Ercan-Herbst, Per Haberkant, David C Schöndorf, Michael Wolf, Salma A Fahim, Enrico Murolo, Dagmar E Ehrnhoefer