日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

BRAF(V600E) patient derived colon cancer organoids identify biomarkers of response to EGFR and BRAF inhibition and replicate clinical data

BRAF(V600E)患者来源的结肠癌类器官可识别EGFR和BRAF抑制剂疗效的生物标志物，并能重现临床数据。

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-026-03699-2
Kotarac, Anna; Osumi, Hiroki; Malt, Alexander; Alp, Keziban Merve; Jarosch, Armin; Werner, Johannes; Benary, Manuela; Neumann, Christopher C M; Yao, Ryoji; Mertins, Philipp; Eils, Roland; Beule, Dieter; Sers, Christine; Keilholz, Ulrich; Ishaque, Naveed; Stintzing, Sebastian; Vecchione, Loredana
肿瘤
肠癌
肿瘤免疫
EGF
BRAF
EGFR
3D/类器官
发表日期：2026
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Atopic Dermatitis (AD) Related Cord Blood DNA Methylation Patterns Are Linked to Maternal AD

特应性皮炎（AD）相关的脐带血DNA甲基化模式与母体AD有关。

期刊:Allergy
影响因子:12
doi:10.1111/all.70130
Matzner, Laura; Denkena, Johanna; Messingschlager, Marey; Seegebarth, Anke; Engelhardt, Rosa; Peng, Zhuoxin; Kheiroddin, Parastoo; Mackowiak, Sebastian D; Brenner, Hermann; Rothenbacher, Dietrich; Ishaque, Naveed; Kabesch, Michael; Eils, Roland; Genuneit, Jon; Trump, Saskia; Lehmann, Irina
DNA甲基化
表观遗传
DNA甲基化
发表日期：2026
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Single-Cell and Spatial Omics: Methods and Applications

单细胞和空间组学：方法和应用

期刊:MedComm
影响因子:10.7
doi:10.1002/mco2.70713
Cen, Xiaoping; Huang, Xiaolan; Deng, Enjin; Gong, Xue; Tan, Na; Ye, Jifeng; Wang, Yin; Eils, Roland; Luo, Qun; Li, Yixue; Qu, Fangfang
细胞生物学
单细胞
发表日期：2026
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HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

HNF1A 和 A1CF 协调 β 细胞转录-剪接轴，该轴在 2 型糖尿病中受到破坏。

期刊:Cell Metabolism
影响因子:27.7
doi:10.1016/j.cmet.2025.07.007.
Edgar Bernardo,Matías Gonzalo De Vas,Diego Balboa,Mirabai Cuenca-Ardura,Sílvia Bonàs-Guarch,Mercè Planas-Fèlix,Fanny Mollandin,Miquel Torrens-Dinarès,Miguel Angel Maestro,Javier García-Hurtado,Sonia Moratinos,Philippe Ravassard,Haiqiang Dou,Holger Heyn,Alexander van Oudenaarden,Nathalie Groen,Eelco de Koning,Christian Conrad,Roland Eils,Santiago Vernia,Patrik Rorsman,Jorge Ferrer
糖尿病
细胞生物学
NF1
发表日期：2025
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Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats

病史可以预测表型范围内的疾病发作，并有助于对新出现的健康威胁做出快速反应。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-55879-x
Steinfeldt, Jakob; Wild, Benjamin; Buergel, Thore; Pietzner, Maik; Upmeier Zu Belzen, Julius; Vauvelle, Andre; Hegselmann, Stefan; Denaxas, Spiros; Hemingway, Harry; Langenberg, Claudia; Landmesser, Ulf; Deanfield, John; Eils, Roland
发表日期：2025
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Author Correction: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats

作者更正：病史可预测表型范围内的疾病发作，并有助于对新出现的健康威胁做出快速反应。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-56429-1
Steinfeldt, Jakob; Wild, Benjamin; Buergel, Thore; Pietzner, Maik; Upmeier Zu Belzen, Julius; Vauvelle, Andre; Hegselmann, Stefan; Denaxas, Spiros; Hemingway, Harry; Langenberg, Claudia; Landmesser, Ulf; Deanfield, John; Eils, Roland
发表日期：2025
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Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

I型干扰素信号通路的重塑与COVID-19的年龄依赖性差异有关

期刊:
影响因子:11.7
doi:PMC12432374
Lev Petrov，Sophia Brumhard，Sebastian Wisniewski，Philipp Georg，David Hillus，Anna Hiller，Rosario Astaburuaga-García，Nils Blüthgen，Emanuel Wyler，Katrin Vogt，Hannah-Philine Dey，Saskia von Stillfried，Christina Iwert，Roman D Bülow，Bruno Märkl，Lukas Maas，Christine Langner，Tim Meyer，Jennifer Loske，Roland Eils，Irina Lehmann，Benjamin Ondruschka，Markus Ralser，Jakob Trimpert，Peter Boor，Sammy Bedoui，Christian Meisel，Marcus A Mall，Victor M Corman，Leif Erik Sander，Jobst Röhmel，Birgit Sawitzki
信号转导
发表日期：2025
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Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

I型干扰素信号通路的重塑与COVID-19的年龄依赖性差异有关

期刊:Cell Reports Medicine
影响因子:11.7
doi:10.1016/j.xcrm.2025.102285
Lev Petrov ，Sophia Brumhard ，Sebastian Wisniewski ，Philipp Georg ，David Hillus ，Anna Hiller ，Rosario Astaburuaga-García ，Nils Blüthgen ，Emanuel Wyler ，Katrin Vogt ，Hannah-Philine Dey ，Saskia von Stillfried ，Christina Iwert ，Roman D Bülow ，Bruno Märkl ，Lukas Maas ，Christine Langner ，Tim Meyer ，Jennifer Loske ，Roland Eils ，Irina Lehmann ，Benjamin Ondruschka ，Markus Ralser ，Jakob Trimpert ，Peter Boor ，Sammy Bedoui ，Christian Meisel ，Marcus A Mall ，Victor M Corman ，Leif Erik Sander ，Jobst Röhmel ，Birgit Sawitzki
信号转导
发表日期：2025
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Sainsc: A Computational Tool for Segmentation-Free Analysis of In Situ Capture Data

Sainsc：一种用于对原位采集数据进行无分割分析的计算工具

期刊:Small Methods
影响因子:9.1
doi:10.1002/smtd.202401123
Müller-Bötticher, Niklas; Tiesmeyer, Sebastian; Eils, Roland; Ishaque, Naveed
发表日期：2025
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DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients' airway epithelial cells.

急性 COVID-19 期间的 DNA 甲基化变化与患者气道上皮细胞的长期转录失调有关

期刊:EMBO Molecular Medicine
影响因子:8.3
doi:10.1038/s44321-025-00215-5
Messingschlager Marey, Mackowiak Sebastian D, Voelker Maria Theresa, Bieg Matthias, Loske Jennifer, Chua Robert Lorenz, Liebig Johannes, Lukassen Sören, Thürmann Loreen, Seegebarth Anke, Twardziok Sven, Doncevic Daria, Herrmann Carl, Lorenz Stephan, Klages Sven, Steinbeis Fridolin, Witzenrath Martin, Kurth Florian, Conrad Christian, Sander Leif E, Ishaque Naveed, Eils Roland, Lehmann Irina, Laudi Sven, Trump Saskia
细胞生物学
发表日期：2025
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