日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PIP4K2C: an emerging fulcrum for multiple diseases

PIP4K2C:多种疾病的新兴支点

Pozzetti, Luca; Mishra, Manjari; Einav, Shirit; Asquith, Christopher R M

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.

PIP4K2C 抑制可逆转 SARS-CoV-2 引起的自噬通量受损

Karim Marwah, Mishra Manjari, Lo Chieh-Wen, Saul Sirle, Cagirici Halise Busra, Gourdelier Manon, Ghita Luca, Ojha Amrita, Tran Do Hoang Nhu, Agrawal Aditi, McGraw Connor, East Michael P, Gammeltoft Karen Anbro, Sahoo Malaya Kumar, Mooney Nancie A, Johnson Gary L, Das Soumita, Leyssen Pieter, Neyts Johan, Chiu Winston, Cohen Courtney A, Bukh Jens, Gottwein Judith, Dye John M, Neff Norma, Jackson Peter K, Pinsky Benjamin A, Laitinen Tuomo, Pantsar Tatu, Poso Antti, Zanini Fabio, De Jonghe Steven, Asquith Christopher R M, Einav Shirit

Discovery of antivirally active inhibitors of adaptor protein-2 associated kinase 1 based on various bicyclic heteroaromatic scaffolds derived from a 7-azaindole analogue

基于源自 7-氮杂吲哚类似物的各种双环杂芳族骨架,发现了具有抗病毒活性的衔接蛋白-2 相关激酶 1 抑制剂

Anthonissen, Stijn; Van Eynde, Wout; Karim, Marwah; Gao, Ling-Jie; Nhu Tran, Do Hoang; Schols, Dominique; Voet, Arnout; Einav, Shirit; Dehaen, Wim; De Jonghe, Steven

Development of pyrazolo[1,5-a]pyrimidine based macrocyclic kinase inhibitors targeting AAK1.

开发以吡唑并[1,5-a]嘧啶为基础的大环激酶抑制剂,靶向AAK1。

Mensing Theresa E, Kurz Christian G, Amrhein Jennifer A, Ehret Theresa A L, Preuss Franziska, Mathea Sebastian, Karim Marwah, Tran Do Hoang Nhu, Kadlecova Zuzana, Tolvanen Tuomas A, Martinez-Molina Daniel, Müller Susanne, Einav Shirit, Knapp Stefan, Hanke Thomas

Comprehensive metabolomics combined with machine learning for the identification of SARS-CoV-2 and other viruses directly from upper respiratory samples

结合代谢组学和机器学习技术,可直接从上呼吸道样本中鉴定SARS-CoV-2和其他病毒。

Hogan, Catherine A; Le, Anthony T; Khan, Afraz; Su, LingHui David; Huang, ChunHong; Sahoo, Malaya K; Lo, Chieh-Wen; Karim, Marwah; Stein, Karin Ann; Einav, Shirit; Cowan, Tina M; Pinsky, Benjamin A

Structure-Activity Relationship Study of 3-Alkynyl-6-aryl-isothiazolo[4,3-b]pyridines as Dual Inhibitors of the Lipid Kinases PIKfyve and PIP4K2C

3-炔基-6-芳基-异噻唑并[4,3-b]吡啶类化合物作为脂质激酶PIKfyve和PIP4K2C双重抑制剂的构效关系研究

Kalebic, Demian; Gao, Ling-Jie; Martinez-Gualda, Belén; Karim, Marwah; Saul, Sirle; Tran, Do Hoang Nhu; Rozenski, Jef; Persoons, Leentje; Schols, Dominique; Dehaen, Wim; Einav, Shirit; De Jonghe, Steven

Scalable single-cell total RNA-seq reveals non-coding programs in immunity, infection, and brain development

可扩展的单细胞总RNA测序揭示了免疫、感染和大脑发育中的非编码程序

Isakova, Alina; Quake, Stephen; Liu, Daniel; Cvijovic, Ivana; Sinha, Rahul; Eastman, Anna; Saul, Sirle; Detweiler, Angela; Neff, Norma; Einav, Shirit; Weissman, Irving

An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.

口服生物利用度高的 SARS-CoV-2 主蛋白酶抑制剂表现出更高的亲和力和更低的突变敏感性

Westberg Michael, Su Yichi, Zou Xinzhi, Huang Pinghan, Rustagi Arjun, Garhyan Jaishree, Patel Puja Bhavesh, Fernandez Daniel, Wu Yan, Hao Chenzhou, Lo Chieh-Wen, Karim Marwah, Ning Lin, Beck Aimee, Saenkham-Huntsinger Panatda, Tat Vivian, Drelich Aleksandra, Peng Bi-Hung, Einav Shirit, Tseng Chien-Te K, Blish Catherine, Lin Michael Z

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

系统免疫学对病毒感染转录反应的研究揭示了猕猴和人类中保守的抗病毒通路。

Ratnasiri, Kalani; Zheng, Hong; Toh, Jiaying; Yao, Zhiyuan; Duran, Veronica; Donato, Michele; Roederer, Mario; Kamath, Megha; Todd, John-Paul M; Gagne, Matthew; Foulds, Kathryn E; Francica, Joseph R; Corbett, Kizzmekia S; Douek, Daniel C; Seder, Robert A; Einav, Shirit; Blish, Catherine A; Khatri, Purvesh

Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors.

2-氨基嘧啶基大环化合物的后口袋优化可得到强效的EPHA2/GAK激酶抑制剂

Gerninghaus Joshua, Zhubi Rezart, Krämer Andreas, Karim Marwah, Tran Do Hoang Nhu, Joerger Andreas C, Schreiber Christian, Berger Lena M, Berger Benedict-Tilman, Ehret Theresa A L, Elson Lewis, Lenz Christopher, Saxena Krishna, Müller Susanne, Einav Shirit, Knapp Stefan, Hanke Thomas