日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Somatic cancer variants enriched in Alzheimer's disease microglia-like cells drive inflammatory and proliferative states

富集于阿尔茨海默病小胶质细胞样细胞中的体细胞癌变异会驱动炎症和增殖状态

Huang, August Yue; Zhou, Zinan; Talukdar, Maya; Enyenihi, Liz; Miller, Michael B; Chhouk, Brian; Rosen, Ila; Zheng, Mengyue; Zhou, Minye; Yang, Averill; Stronge, Edward; Durens, Madel; Nguyen, Minh; Choi, Jaejoon; Zhao, Boxun; Khoshkhoo, Sattar; Kim, Junho; Andersen, Rebecca; An, Zheming; Cheng, Yuchen; Ganz, Javier; Mekerishvili, Levan; Travaglini, Kyle J; Gabitto, Mariano I; Hodge, Rebecca D; Kaplan, Eitan S; Belk, Julia A; Landau, Dan; Lein, Ed S; De Jager, Philip L; Bennett, David A; Marro, Samuele G; Papapetrou, Eirini P; Lee, Eunjung Alice; Walsh, Christopher A

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia.

儿童白血病的致癌潜能、谱系等级和治疗反应由个体发育决定。

Wang Ke, Saniei Shayan, Poddar Nikita, Martinez Isabella G, Chao Clifford, Autar Subrina, Fiore Persephone, Carcamo Saul, Sreenath Meghana, Peplinski Jack H, Ries Rhonda E, Mei Anna Huo-Chang, Rahman Noshin Azra, Mekerishvili Levan, Quijada-Álamo Miguel, Freed Grace, Zhang Mimi, Lachman Katherine, Diaz Zayna, Gonzalez Manuel M, Zhang Jing, Pham Giang, Filipescu Dan, Berisa Mirela, Balestra Tommaso, Wheeler Noelle, Reisz Julie A, D'Alessandro Angelo, Puleston Daniel J, Bernstein Emily, Chipuk Jerry E, Wunderlich Mark, Tasian Sarah K, Marcellino Bridget K, Glass Ian A, Sturgeon Christopher M, Landau Dan A, Chen Zhihong, Papapetrou Eirini P, Izzo Franco, Meshinchi Soheil, Hasson Dan, Wagenblast Elvin

Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2-mutated post-MPN AML

新型 BCL-xL 降解剂 DT2216 在 JAK2 突变型 MPN 后 AML 临床前模型中的疗效

Wang, Zhe; Skwarska, Anna; Poigaialwar, Gowri; Chaudhry, Sovira; Rodriguez-Meira, Alba; Sui, Pinpin; Olivier, Emmanuel; Jia, Yannan; Gupta, Varun; Fiskus, Warren; Ramage, Cassandra L; Zheng, Guangrong; Schurer, Alexandra; Gritsman, Kira; Papapetrou, Eirini P; Bhalla, Kapil; Zhou, Daohong; Mead, Adam J; Rampal, Raajit K; Tyner, Jeffrey W; Abbas, Hussein A; Pemmaraju, Naveen; Tatarata, Qi Zhang; Konopleva, Marina

Cell-autonomous dysregulation of interferon signaling drives clonal expansion of SRSF2-mutant MDS stem/progenitor cells.

干扰素信号传导的细胞自主失调驱动 SRSF2 突变 MDS 干/祖细胞的克隆扩增

Takashima Kouhei, Olszewska Malgorzata, Jethalia Vrinda, Sirenko Maria, Silverman Lewis, Tomalin Lewis E, Carcamo Saul, Hasson Dan, Papapetrou Eirini P

TET2-mutant myeloid cells mitigate Alzheimer's disease progression via CNS infiltration and enhanced phagocytosis in mice

TET2突变髓系细胞通过中枢神经系统浸润和增强吞噬作用来减轻小鼠阿尔茨海默病的进展。

Matatall, Katie A; Wathan, Trisha K; Nguyen, Minh; Chen, Hu; McDonald, Alexandra; Qi, Guantong; Belk, Julia A; Florez, Marcus A; Le, Duy T; Olarinde, Temitope; Vlasschaert, Caitlyn; Buttigieg, Marco M; Fan, Chih-Wei; Carcamo, Saul; Cao, Ruoqiong; Kennedy, Daniel E 2nd; Maknojia, Arushana A; Thatavarty, Apoorva; Fernandez Sanchez, Josaura V; Bouzid, Hind; Veeraragavan, Surabi; Crocker, Susan; Goodell, Margaret A; Rodriguez, Antony; Jaiswal, Siddhartha; Rauh, Michael J; Papapetrou, Eirini P; Marro, Samuele G; King, Katherine Y

Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia.

对 IDH 突变型急性髓系白血病中的克隆和细胞结构进行解卷积。

Sirenko Maria, Lee Soobeom, Sun Zhengxi, Chaligne Ronan, Loghavi Sanam, Asimomitis Georgios, Brierley Charlotte K, Bernard Elsa, Cai Sheng F, Myers Robert M, Nadorp Bettina, Sango Junya, Lallo Morgan, Levine Max F, Domenico Dylan, Arango Ossa Juan E, Medina-Martinez Juan S, Menghrajani Kamal, Lasry Audrey, Mims Alice S, Desai Helee, Laganson Andrea, Famulare Chris, Patel Minal, Lozanski Gerard, Bolton Kelly L, Viny Aaron D, Roshal Mikhail, Levine Ross L, Papapetrou Eirini P, Stein Eytan M, Landau Dan A, Eisfeld Ann-Kathrin, Aifantis Iannis, Papaemmanuil Elli

TET2-mutant myeloid cells mitigate Alzheimer's disease progression via CNS infiltration and enhanced phagocytosis in mice

TET2突变髓系细胞通过中枢神经系统浸润和增强吞噬作用来减轻小鼠阿尔茨海默病的进展。

Katie A Matatall ,Trisha K Wathan ,Minh Nguyen ,Hu Chen ,Alexandra McDonald ,Guantong Qi ,Julia A Belk ,Marcus A Florez ,Duy T Le ,Temitope Olarinde ,Caitlyn Vlasschaert ,Marco M Buttigieg ,Chih-Wei Fan ,Saul Carcamo ,Ruoqiong Cao ,Daniel E Kennedy 2nd ,Arushana A Maknojia ,Apoorva Thatavarty ,Josaura V Fernandez Sanchez ,Hind Bouzid ,Surabi Veeraragavan ,Susan Crocker ,Margaret A Goodell ,Antony Rodriguez ,Siddhartha Jaiswal ,Michael J Rauh ,Eirini P Papapetrou ,Samuele G Marro ,Katherine Y King

A heterozygous CEBPA mutation disrupting the bZIP domain in a RUNX1 and SRSF2 mutational background causes MDS disease progression.

在 RUNX1 和 SRSF2 突变背景下,杂合 CEBPA 突变破坏了 bZIP 结构域,导致 MDS 疾病进展

Almaghrabi Ruba, Alyahyawi Yara, Keane Peter, Mian Syed A, Habel Khadidja, Atkinson Amelia, Ward Carl, Bayley Rachel, Sargas Claudia, Menendez Pablo, Murphy George J, Sobahy Turki, Baghdadi Mohammed A, Flemban Arwa F, Kabrah Saeed M, Torres-Ruiz Raul, Papapetrou Eirini P, Akerman Ildem, Raghavan Manoj, Barragan Eva, Bonnet Dominique, Bonifer Constanze, Garcia Paloma

Natural killer cells' functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes

自然杀伤细胞功能障碍导致早期骨髓增生异常综合征中癌前克隆细胞逃避免疫攻击。

Juan Jose Rodriguez-Sevilla #,Irene Ganan-Gomez #,Bijender Kumar #,Natthakan Thongon,Feiyang Ma,Kelly S Chien,Yi J Kim,Hui Yang,Sanam Loghavi,Roselyn Tan,Vera Adema,Zongrui Li,Tomoyuki Tanaka,Hidetaka Uryu,Rashmi Kanagal-Shamanna,Gheath Al-Atrash,Rafael Bejar,Pinaki Prosad Banerjee,Sophia Lynn Cha,Guillermo Montalban-Bravo,Max Dougherty,Maria Claudina Fernandez Laurita,Noelle Wheeler,Baosen Jia,Eirini P Papapetrou,Franco Izzo,Daniela E Dueñas,Salome McAllen,Yiqian Gu,Gabriele Todisco,Francesca Ficara,Matteo Giovanni Della Porta,Abhinav Jain,Koichi Takahashi,Karen Clise-Dwyer,Stephanie Halene,Maria Teresa Sabrina Bertilaccio,Guillermo Garcia-Manero,May Daher,Simona Colla

SF3B1-mutant models of RNA mis-splicing uncover UBA1 as a therapeutic target in myelodysplastic neoplasms

SF3B1突变RNA剪接错误模型揭示UBA1是骨髓增生异常综合征的治疗靶点

Thier, Jonas; Hofmann, Sophia; Kirchhof, Katharina M; Todisco, Gabriele; Mortera-Blanco, Teresa; Lilienthal, Ingrid; Kanellis, Dimitris C; Barbosa, Indira; Björklund, Ann-Charlotte; Deslauriers, André G; Bartek, Jiri; Herold, Nikolas; Papaemmanuil, Elli; Papapetrou, Eirini P; Hellström-Lindberg, Eva; Moura, Pedro L; Lundin, Vanessa