日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity

ROCK 的治疗调节可克服癌细胞对 OXPHOS 抑制的代谢适应并促进协同抗肿瘤活性

Nicholas Blazanin, Xiaobing Liang, Iqbal Mahmud, Eiru Kim, Sara Martinez, Lin Tan, Waikin Chan, Nazanin Esmaeili Anvar, Min Jin Ha, Md Qudratullah, Rosalba Minelli, Michael Peoples, Philip Lorenzi, Traver Hart, Yonathan Lissanu

HumanNet v3: an improved database of human gene networks for disease research

HumanNet v3:一个改进的人类基因网络数据库,用于疾病研究

Kim, Chan Yeong; Baek, Seungbyn; Cha, Junha; Yang, Sunmo; Kim, Eiru; Marcotte, Edward M; Hart, Traver; Lee, Insuk

Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions

通过上下文相关的功能相互作用揭示跨基因型和谱系的生物活性动态重构

Eiru Kim, Lance C Novak, Chenchu Lin, Medina Colic, Lori L Bertolet, Veronica Gheorghe, Christopher A Bristow, Traver Hart

Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells.

通过 CRISPR 筛选发现假定的肿瘤抑制因子,揭示了急性髓系白血病细胞中脂质代谢的重塑

Lenoir W Frank, Morgado Micaela, DeWeirdt Peter C, McLaughlin Megan, Griffith Audrey L, Sangree Annabel K, Feeley Marissa N, Esmaeili Anvar Nazanin, Kim Eiru, Bertolet Lori L, Colic Medina, Dede Merve, Doench John G, Hart Traver

Improved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifier

利用 BAGEL2 基因必需性分类器改进 CRISPR 适应性筛选分析并减少脱靶效应

Kim, Eiru; Hart, Traver

AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase

AR 阴性前列腺癌容易因 JMJD1C 去甲基化酶的缺失而受损

Yohei Yoshihama, Kyle A LaBella, Eiru Kim, Lori Bertolet, Medina Colic, Jiexi Li, Xiaoying Shang, Chang-Jiun Wu, Denise J Spring, Y Alan Wang, Traver Hart, Ronald A DePinho

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

癌症固有逃避T细胞杀伤的功能基因组图谱

Keith A Lawson #,Cristovão M Sousa #,Xiaoyu Zhang,Eiru Kim,Rummy Akthar,Joseph J Caumanns,Yuxi Yao,Nicholas Mikolajewicz,Catherine Ross,Kevin R Brown,Abdelrahman Abou Zid,Zi Peng Fan,Shirley Hui,Jordan A Krall,Donald M Simons,Chloe J Slater,Victor De Jesus,Lujia Tang,Richa Singh,Joshua E Goldford,Sarah Martin,Qian Huang,Elizabeth A Francis,Andrea Habsid,Ryan Climie,David Tieu,Jiarun Wei,Ren Li,Amy Hin Yan Tong,Michael Aregger,Katherine S Chan,Hong Han,Xiaowei Wang,Patricia Mero,John H Brumell,Antonio Finelli,Laurie Ailles,Gary Bader,Gromoslaw A Smolen,Gillian A Kingsbury,Traver Hart,Charles Kung,Jason Moffat

Multiplex enCas12a screens detect functional buffering among paralogs otherwise masked in monogenic Cas9 knockout screens

多重 enCas12a 筛选可以检测出旁系同源基因之间的功能性缓冲作用,而这种作用在单基因 Cas9 敲除筛选中会被掩盖。

Dede, Merve; McLaughlin, Megan; Kim, Eiru; Hart, Traver

BiomeNet: a database for construction and analysis of functional interaction networks for any species with a sequenced genome

BiomeNet:一个用于构建和分析任何已测序基因组物种的功能相互作用网络的数据库

Kim, Eiru; Bae, Dasom; Yang, Sunmo; Ko, Gunhwan; Lee, Sungho; Lee, Byungwook; Lee, Insuk

HumanNet v2: human gene networks for disease research

HumanNet v2:用于疾病研究的人类基因网络

Hwang, Sohyun; Kim, Chan Yeong; Yang, Sunmo; Kim, Eiru; Hart, Traver; Marcotte, Edward M; Lee, Insuk