El Rayes相关文献与解析，生知库 | 链接生命科学的每一步

High-Dimensional Protein Analysis Uncovers Distinct Immunologic and Stromal Features in Primary and Metastatic Pancreatic Ductal Adenocarcinoma.

高维蛋白质分析揭示原发性和转移性胰腺导管腺癌的独特免疫学和基质特征。

Greene Emily, Horvat Natalie K, Doxie Deon Bryant, Parihar Vaunita Cohen, Kim Jayden, Herting Cameron J, Grundy Erin E, Ruffin Ayana T, Krasinskas Alyssa M, Maithel Shishir K, Sarmiento Juan M, Shah Mihir M, Zaidi Mohammad Y, Diab Maria, Alese Olatunji B, Dhodapkar Kavita, Kissick Haydn T, El-Rayes Bassel F, Paulos Chrystal M, Lesinski Gregory B

免疫/内分泌

发表日期：2026

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A phase Ib/II trial of XL888 (HSP90 inhibitor) and pembrolizumab in metastatic pancreatic cancer with translational immune profiling

一项针对转移性胰腺癌的 XL888（HSP90 抑制剂）联合帕博利珠单抗的 Ib/II 期临床试验，并结合转化免疫分析。

期刊:Cancer Letters

影响因子:10.1

doi:10.1016/j.canlet.2025.218233

Horvat, Natalie K; Diab, Maria; Phillips, Maggie J; McCook-Veal, Ashley; Grundy, Erin E; Alese, Olatunji B; Greene, Emily; Gbolahan, Olumide; Coleman, Kathleen; Doxie, Deon; Herting, Cameron J; Hammons, Jacklyn; Mahdi, Zaid; Switchenko, Jeffrey M; Paulos, Chrystal M; El-Rayes, Bassel F; Lesinski, Gregory B

Extracellular Vesicles in Tauopathies: Mechanisms and Applications

tau蛋白病中的细胞外囊泡：机制和应用

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms27041998

Nannuri, Varun; Ababneh, Ebaa; El Rayes, Serena; Smith, Jonhoi; Sugaya, Kiminobu; Zhao, Jihe

Reproductive performance and physiological responses of Barki does fed Spanish panicum and cassava (Manihot esculenta) as alternatives to berseem hay.

以西班牙黍和木薯（Manihot esculenta）代替苜蓿干草饲喂巴尔基母羊，研究其繁殖性能和生理反应。

期刊:BMC Veterinary Research

影响因子:2.6

doi:10.1186/s12917-025-05267-w

El-Maghraby Emad F, El-Hawy Ahmed S, Sahwan Ferial M, El-Rayes Muhammed Ahmed-Hilmy, Elghareeb Mona M, Zedan Afaf H, Elshopakey Gehad E, Abdelrahman Hisham A, Sakr Shimaa A

NTA

发表日期：2026

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Effects of dried Azolla pinnata supplementation on growth, biochemistry, and reproduction in female rabbits

干满江红补充剂对雌兔生长、生化和繁殖的影响

期刊:Tropical Animal Health and Production

影响因子:1.7

doi:10.1007/s11250-026-04966-2

Abd-Elfadiel Hagag, Omnia Y; Ahmed-Helmy El-Rayes, Muhammed; El-Hawy, Ahmed S; Nabil, Zhou I; El-Shenawy, Nahla Soliman

发表日期：2026

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ProAgio, a Novel Integrin αvβ3 Targeted Cytotoxin, Suppresses Tumor Growth and Reprograms the PDAC Microenvironment

ProAgio是一种新型的靶向整合素αvβ3的细胞毒素，可抑制肿瘤生长并重编程PDAC微环境。

期刊:

影响因子:

doi:10.64898/2026.01.15.699725

Bandi, Dhana Sekhar Reddy; Sarvesh, Sujith; Nagaraju, Ganji Purnachandra; Kim, Harrison; Foote, Jeremy; Bae, Sejong; Yoon, Karina J; Malla, Midhun; Masood, Ashiq; Akce, Mehmet; Liu, Zhi-Ren; El-Rayes, Bassel F

ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma

ADT-030 是一种新型 PDE10 抑制剂，在胰腺导管腺癌中表现出强大的抗肿瘤活性。

期刊:

影响因子:

doi:10.64898/2026.02.11.705411

Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Foote, Jeremy B; Keeton, Adam B; Chen, Xi; Ramirez-Alcantara, Veronica; Holmes, Thomas; Akce, Mehmet; Singh, Anju; Powell, Craig M; Behera, Santosh; Azmi, Asfar S; Nurmemmedov, Elmar; Babic, Ivan; Gorman, Gregory S; Coward, Lori; Buchsbaum, Donald J; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F

Targeting KRAS mutations: orchestrating cancer evolution and therapeutic challenges

靶向KRAS突变：调控癌症演变和治疗挑战

期刊:Signal Transduction and Targeted Therapy

影响因子:52.7

doi:10.1038/s41392-025-02473-8

Choucair, Khalil; Imtiaz, Hafsa; Uddin, Md Hafiz; Nagasaka, Misako; Al-Hallak, Mohammad Najeeb; Philip, Philip A; El-Rayes, Bassel; Pasche, Boris C; Azmi, Asfar S

ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma

ADT-1004：一种首创的口服泛RAS抑制剂，在胰腺导管腺癌的临床前模型中具有强大的抗肿瘤活性

期刊:Molecular Cancer

影响因子:33.9

doi:10.1186/s12943-025-02288-9

Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Carstens, Julienne L; Foote, Jeremy B; Graff, Emily C; Fang, Yu-Hua D; Keeton, Adam B; Chen, Xi; Valiyaveettil, Jacob; Berry, Kristy L; Bae, Sejong; Akce, Mehmet; Gorman, Greg; Yoon, Karina J; Manne, Upender; Boyd, Michael R; Buchsbaum, Donald J; Azmi, Asfar S; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F

Autophagy in cancer-associated fibroblasts: its role in gastrointestinal cancers

癌症相关成纤维细胞中的自噬：其在胃肠道癌症中的作用

High-Dimensional Protein Analysis Uncovers Distinct Immunologic and Stromal Features in Primary and Metastatic Pancreatic Ductal Adenocarcinoma.

高维蛋白质分析揭示原发性和转移性胰腺导管腺癌的独特免疫学和基质特征。

A phase Ib/II trial of XL888 (HSP90 inhibitor) and pembrolizumab in metastatic pancreatic cancer with translational immune profiling

一项针对转移性胰腺癌的 XL888（HSP90 抑制剂）联合帕博利珠单抗的 Ib/II 期临床试验，并结合转化免疫分析。

Extracellular Vesicles in Tauopathies: Mechanisms and Applications

tau蛋白病中的细胞外囊泡：机制和应用

Reproductive performance and physiological responses of Barki does fed Spanish panicum and cassava (Manihot esculenta) as alternatives to berseem hay.

以西班牙黍和木薯（Manihot esculenta）代替苜蓿干草饲喂巴尔基母羊，研究其繁殖性能和生理反应。

Effects of dried Azolla pinnata supplementation on growth, biochemistry, and reproduction in female rabbits

干满江红补充剂对雌兔生长、生化和繁殖的影响

ProAgio, a Novel Integrin αvβ3 Targeted Cytotoxin, Suppresses Tumor Growth and Reprograms the PDAC Microenvironment

ProAgio是一种新型的靶向整合素αvβ3的细胞毒素，可抑制肿瘤生长并重编程PDAC微环境。

ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma

ADT-030 是一种新型 PDE10 抑制剂，在胰腺导管腺癌中表现出强大的抗肿瘤活性。

Targeting KRAS mutations: orchestrating cancer evolution and therapeutic challenges

靶向KRAS突变：调控癌症演变和治疗挑战

ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma

ADT-1004：一种首创的口服泛RAS抑制剂，在胰腺导管腺癌的临床前模型中具有强大的抗肿瘤活性