Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model
在小鼠哮喘模型中,Src依赖的EGFR反式激活通过下游信号通路(包括ERK1/2、PI3Kδ/Akt和NFκB的诱导)调节肺部炎症。
期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-017-09349-0
El-Hashim, Ahmed Z; Khajah, Maitham A; Renno, Waleed M; Babyson, Rhema S; Uddin, Mohib; Benter, Ibrahim F; Ezeamuzie, Charles; Akhtar, Saghir
信号转导
EGFR
哮喘
EGF
炎症
肺炎
炎症/感染
MAPK/ERK