日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Conventional and Rock-Based Potassium Fertilization Improves Fennel (Foeniculum vulgare Mill.) Performance Under Extended Irrigation Intervals

常规钾肥和岩基钾肥均能改善延长灌溉间隔下茴香（Foeniculum vulgare Mill.）的生长性能

期刊:Plants-Basel
影响因子:4.1
doi:10.3390/plants15040573
El-Sheref, Ghada F H; Elhawat, Nevien; Kenawy, A G M; Mohamed, Gihan A; Shabana, Mahmoud M A; Alshaal, Tarek
发表日期：2026
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Design, synthesis, and antiproliferative activity of new 2-amino-pyrano[3,2-c]quinoline-3-carbonitriles as potential EGFR, BRAF(V600E), and HER-2 inhibitors

新型2-氨基吡喃并[3,2-c]喹啉-3-腈类化合物的设计、合成及其作为潜在EGFR、BRAF(V600E)和HER-2抑制剂的抗增殖活性

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra04276c
Al-Wahaibi, Lamya H; Mohassab, Aliaa M; Rabea, Safwat M; Youssif, Bahaa G M; Bräse, Stefan; El-Sheref, Essmat M
EGFR
EGF
BRAF
发表日期：2025
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Convenient synthesis and X-ray determination of 2-amino-6H-1,3,4-thiadiazin-3-ium bromides endowed with antiproliferative activity

简便合成及X射线测定具有抗增殖活性的2-氨基-6H-1,3,4-噻二嗪-3-溴化物

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d4ra02531h
Tawfeek, Hendawy N; Abdelmoez, Alshaimaa; Dahlous, Kholood A; Youssif, Bahaa G M; Bräse, Stefan; Rissanen, Kari; Nieger, Martin; El-Sheref, Essmat M
发表日期：2024
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Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF(V600E) inhibitors

合成一系列具有凋亡抑制和抗增殖作用的新型4-吡唑基喹啉酮类化合物，作为双重EGFR/BRAF(V600E)抑制剂

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d4md00230j
Al-Wahaibi, Lamya H; Youssif, Bahaa G M; Abou-Zied, Hesham A; Bräse, Stefan; Brown, Alan B; Tawfeek, Hendawy N; El-Sheref, Essmat M
EGFR
BRAF
表观遗传
EGF
凋亡
发表日期：2024
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Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors

4-(1,2,3-三唑-1-基)喹啉-2(1H)-酮作为多靶点抑制剂的合成、抗氧化和抗增殖作用

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms241713300
El-Sheref, Essmat M; Bräse, Stefan; Tawfeek, Hendawy N; Alasmary, Fatmah Ali; Youssif, Bahaa G M
发表日期：2023
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Hypokalemia as a responsible factor related with the severity of hepatic encephalopathy: a wide multination cross-sectional study

低钾血症是肝性脑病严重程度的相关因素：一项广泛的多国横断面研究

期刊:Annals of Medicine and Surgery
影响因子:1.6
doi:10.1097/MS9.0000000000000470
Ullah, Himayat; Shabana, Hossam; Rady, Mohamed Akl; Abdelsameea, Eman; Youssef, Mohamed I; Helmy, Housam Ahmed; Mustafa, Ghulam; Elghafar, Tamer Samir Abd; Almarshad, Feras; Alshahrani, Abdulrahman; Abdel-Samiee, Mohamed; Alwadai, Abdulmajeed Ahmed; Zedan, Hendawy Abdel-Moety; Khalil, Farag; Ahmed, Mahmoud Osama; Kassem, Arafat; Omar, Marwa M; Kamel, Shimaa Y; El Sheref, Saad El Deen Mohamed; Hassan, Mohamed Hassan Attia; AboShabaan, Hind S; Elgendy, Wagih; Zaghloul, Amr M; Mohamed, Ibrahim Ghoniem Ramadan; Zayed, Esam; Abdelghaffar, Amir; Aboufarrag, Galal Abdelhameed; Seif, A S; Elmahdy, Hussein Ahmed; Said, Ashraf; Farahat, Ali; El-Sayed Lashin, Hesham; Elmahdi, Essam; Abuamer, Ahmed
神经科学
低钾血症
免疫/内分泌
发表日期：2023
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Synthesis of novel amidines via one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties

通过一锅三组分反应合成新型脒类化合物：具有抗增殖特性的选择性拓扑异构酶I抑制剂

期刊:Frontiers in Chemistry
影响因子:4.2
doi:10.3389/fchem.2022.1039176
El-Sheref, Essmat M; Tawfeek, Hendawy N; Hassan, Alaa A; Bräse, S; Elbastawesy, Mohammed A I; Gomaa, Hesham A M; Mostafa, Yaser A; Youssif, Bahaa G M
发表日期：2022
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Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents

通过点击反应设计合成(2-氧代-1,2-二氢喹啉-4-基)-1,2,3-三唑衍生物：潜在的凋亡抑制抗增殖剂

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules26226798
El-Sheref, Essmat M; Elbastawesy, Mohammed A I; Brown, Alan B; Shawky, Ahmed M; Gomaa, Hesham A M; Bräse, Stefan; Youssif, Bahaa G M
表观遗传
凋亡
发表日期：2021
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Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/ Bis-2(1 H)-Quinolinone Hybrids

新型 1,2,3-三唑/双-2(1 H)-喹啉酮杂化物的设计、合成、分子对接、抗凋亡和 Caspase-3 抑制作用

期刊:Molecules
影响因子:4.2
doi:10.3390/molecules25215057
Essmat M El-Sheref, Ashraf A Aly, Mohammed B Alshammari, Alan B Brown, Sara Mohamed Naguib Abdel-Hafez, Walaa Yehia Abdelzaher, Stefan Bräse, ElShimaa M N Abdelhafez
信号转导
细胞生物学
Apoptosis
发表日期：2020
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Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma

设计、合成并生物学评价稠合萘并呋喃并[3,2-c]喹啉-6,7,12-三酮和吡喃并[3,2-c]喹啉-6,7,8,13-四酮衍生物作为ERK抑制剂在BRAF突变型黑色素瘤中的疗效

期刊:Bioorganic Chemistry
影响因子:4.7
doi:10.1016/j.bioorg.2018.10.044
Aly, Ashraf A; El-Sheref, Essmat M; Bakheet, Momtaz E M; Mourad, Mai A E; Bräse, Stefan; Ibrahim, Mahmoud A A; Nieger, Martin; Garvalov, Boyan K; Dalby, Kevin N; Kaoud, Tamer S
BRAF
黑色素瘤
MAPK/ERK
发表日期：2019
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