Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305
配体结合促进 ER-α 铰链区丝氨酸 294 的 CDK 依赖性磷酸化,但抑制丝氨酸 305 的配体非依赖性磷酸化。
期刊:Molecular Cancer Research
影响因子:4.7
doi:10.1158/1541-7786.MCR-12-0099
Held, Jason M; Britton, David J; Scott, Gary K; Lee, Elbert L; Schilling, Birgit; Baldwin, Michael A; Gibson, Bradford W; Benz, Christopher C