A PDE1 inhibitor, vinpocetine, ameliorates epithelial-mesenchymal transition and renal fibrosis in adenine-induced chronic kidney injury in rats by targeting the DNMT1/Klotho/β-catenin/Snail 1 and MMP-7 pathways.
PDE1 抑制剂长春西汀通过靶向 DNMT1/Klotho/β-catenin/Snail 1 和 MMP-7 通路，改善腺嘌呤诱导的大鼠慢性肾损伤中的上皮-间质转化和肾纤维化
期刊:Naunyn-Schmiedebergs Archives of Pharmacology
影响因子:3.1
doi:10.1007/s00210-024-03393-0
Abdelfattah Amira Mohammed, Mohammed Zeinab A, Talaat Aliaa, Samy Walaa, Eldesoqui Mamdouh, Elgarhi Reham I
