日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM

上皮-间质转化通过抑制 BIM 来抑制肺癌靶向治疗的反应

Kyung-A Song #, Matthew J Niederst #, Timothy L Lochmann, Aaron N Hata, Hidenori Kitai, Jungoh Ham, Konstantinos V Floros, Mark A Hicks, Haichuan Hu, Hillary E Mulvey, Yotam Drier, Daniel A R Heisey, Mark T Hughes, Neha U Patel, Elizabeth L Lockerman, Angel Garcia, Shawn Gillepsie, Hannah L Archibal

Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor

使用第三代 EGFR 抑制剂治疗 T790M 阳性癌症后,EGFRT790 野生型克隆的出现源于异质性

Zofia Piotrowska, Matthew J Niederst, Chris A Karlovich, Heather A Wakelee, Joel W Neal, Mari Mino-Kenudson, Linnea Fulton, Aaron N Hata, Elizabeth L Lockerman, Anuj Kalsy, Subba Digumarthy, Alona Muzikansky, Mitch Raponi, Angel R Garcia, Hillary E Mulvey, Melissa K Parks, Richard H DiCecca, Dora Di

Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations

通过 MAPK 通路改变,BRAF 突变型结直肠癌对 RAF 抑制剂组合产生临床获得性耐药性

Leanne G Ahronian, Erin M Sennott, Eliezer M Van Allen, Nikhil Wagle, Eunice L Kwak, Jason E Faris, Jason T Godfrey, Koki Nishimura, Kerry D Lynch, Craig H Mermel, Elizabeth L Lockerman, Anuj Kalsy, Joseph M Gurski Jr, Samira Bahl, Kristin Anderka, Lisa M Green, Niall J Lennon, Tiffany G Huynh, Mari

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

耐药性 EGFR 突变肺腺癌转化为小细胞肺癌时 RB 丢失

Matthew J Niederst, Lecia V Sequist, John T Poirier, Craig H Mermel, Elizabeth L Lockerman, Angel R Garcia, Ryohei Katayama, Carlotta Costa, Kenneth N Ross, Teresa Moran, Emily Howe, Linnea E Fulton, Hillary E Mulvey, Lindsay A Bernardo, Farhiya Mohamoud, Norikatsu Miyoshi, Paul A VanderLaan, Daniel

The Allelic Context of the C797S Mutation Acquired upon Treatment with Third-Generation EGFR Inhibitors Impacts Sensitivity to Subsequent Treatment Strategies

第三代 EGFR 抑制剂治疗后获得的 C797S 突变的等位基因背景影响对后续治疗策略的敏感性

Matthew J Niederst, Haichuan Hu, Hillary E Mulvey, Elizabeth L Lockerman, Angel R Garcia, Zofia Piotrowska, Lecia V Sequist, Jeffrey A Engelman

Cabozantinib overcomes crizotinib resistance in ROS1 fusion-positive cancer

卡博替尼可克服 ROS1 融合阳性癌症中的克唑替尼耐药性

Ryohei Katayama, Yuka Kobayashi, Luc Friboulet, Elizabeth L Lockerman, Sumie Koike, Alice T Shaw, Jeffrey A Engelman, Naoya Fujita

Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways

抑制肺癌细胞中的突变 EGFR 可触发 SOX2-FOXO6 依赖性生存途径

S Michael Rothenberg, Kyle Concannon, Sarah Cullen, Gaylor Boulay, Alexa B Turke, Anthony C Faber, Elizabeth L Lockerman, Miguel N Rivera, Jeffrey A Engelman, Shyamala Maheswaran, Daniel A Haber

Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib

两种新型 ALK 突变导致对下一代 ALK 抑制剂阿来替尼产生获得性耐药性

Ryohei Katayama, Luc Friboulet, Sumie Koike, Elizabeth L Lockerman, Tahsin M Khan, Justin F Gainor, A John Iafrate, Kengo Takeuchi, Makoto Taiji, Yasushi Okuno, Naoya Fujita, Jeffrey A Engelman, Alice T Shaw0