日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons

连续CRISPR筛选揭示,部分抑制NatB是降低人类神经元中α-突触核蛋白水平的一种策略。

Saranya Santhosh Kumar ,Nima N Naseri ,Sarshan R Pather ,Erinc Hallacli ,Alain Ndayisaba ,Chris Buenaventura ,Karen Acosta ,Jennifer Roof ,Hossein Fazelinia ,Lynn A Spruce ,Kelvin Luk ,Vikram Khurana ,Elizabeth Rhoades ,Ophir Shalem

Simple visualization of submicroscopic protein clusters with a phase-separation-based fluorescent reporter

使用基于相分离的荧光报告器简单可视化亚微观蛋白质簇

Thomas R Mumford, Diarmid Rae, Emily Brackhahn, Abbas Idris, David Gonzalez-Martinez, Ayush Aditya Pal, Michael C Chung, Juan Guan, Elizabeth Rhoades, Lukasz J Bugaj

Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors

通过细胞时间分辨 FRET 生物传感器鉴定出毒性 α-突触核蛋白的强效抑制剂

Anthony R Braun, Elly E Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D Evans, William C K Pomerantz, Elizabeth Rhoades, Kelvin Luk, Razvan L Cornea, David D Thomas, Jonathan N Sachs

Structural Characterization of Tau in Fuzzy Tau:Tubulin Complexes

模糊Tau蛋白:微管蛋白复合物中Tau蛋白的结构表征

Ho Yee Joyce Fung ,Kristen M McKibben ,Jennifer Ramirez ,Kushol Gupta ,Elizabeth Rhoades

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

针对细胞内异质性 tau 寡聚体集合:一种用于 tau 蛋白病的新型小分子筛选平台

Chih Hung Lo, Colin Kin-Wye Lim, Zhipeng Ding, Sanjula P Wickramasinghe, Anthony R Braun, Karen H Ashe, Elizabeth Rhoades, David D Thomas, Jonathan N Sachs

Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein

鉴定 N 连接聚糖作为乙酰化 α-突触核蛋白神经元摄取的特异性介质

Melissa Birol, Slawomir P Wojcik, Andrew D Miranker, Elizabeth Rhoades

Independent tubulin binding and polymerization by the proline-rich region of Tau is regulated by Tau's N-terminal domain

Tau 富含脯氨酸区域的独立微管蛋白结合和聚合受 Tau 的 N 端结构域调控

Kristen M McKibben, Elizabeth Rhoades

Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity

环化 NDGA 修饰动态 α-突触核蛋白单体,防止聚集和毒性

Malcolm J Daniels, J Brucker Nourse Jr, Hanna Kim, Valerio Sainati, Marco Schiavina, Maria Grazia Murrali, Buyan Pan, John J Ferrie, Conor M Haney, Rani Moons, Neal S Gould, Antonino Natalello, Rita Grandori, Frank Sobott, E James Petersson, Elizabeth Rhoades, Roberta Pierattelli, Isabella Felli, Vl

Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid

动态低聚物内的构象转换是糖尿病相关淀粉样蛋白获得毒性功能的基础

Melissa Birol, Sunil Kumar, Elizabeth Rhoades, Andrew D Miranker

Foldamer-mediated manipulation of a pre-amyloid toxin

折叠体介导的前淀粉样毒素的操纵

Sunil Kumar, Melissa Birol, Diana E Schlamadinger, Slawomir P Wojcik, Elizabeth Rhoades, Andrew D Miranker