日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bioengineered iPSC-derived human macrophages with increased angiotensin-converting enzyme (ACE) expression suppress solid tumor growth.

生物工程改造的 iPSC 衍生的人类巨噬细胞,其血管紧张素转换酶 (ACE) 表达增加,可抑制实体瘤的生长。

Shibata Tomohiro, Bhat Shabir, Cao DuoYao, Saito Suguru, Khan Noor, Bernstein Ellen A, Tokudome Takeshi, Okwan-Duodu Derick, Tourtellotte Warren G, Bernstein Kenneth E, Khan Zakir

Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy

反义寡核苷酸介导的基因敲低疗法治疗两名患有严重KCNT1癫痫性脑病的婴儿

Nakayama, Tojo; El Achkar, Christelle M; Burbano, Lisseth E; Quraishi, Imran H; Wu, Jing; Li, Melody; Asami, Yutaro; Golinski, Sean R; Sherrill, Emma; Goodlett, Benjamin D; de Gusmao, Claudio M; Friedman, Danielle A; Lentucci, Claudia; Suslovitch, Victoria; Riccardi, Olivia; Faour, Kamli N W; Kuniholm, Ashley; Soucy Verran, Aubrie; Coffman, Siobhan; Ahtam, Banu; Zhao, Boxun; Chin, Diana H; DiDonato, Renata L; Hu, Chunguang A; Lopez, Edith; Hills, Sonia; Maljevic, Snezana; Tran, Helene; Bush, Lynn W; Grant, Patricia Ellen; Madsen, Joseph R; Smith, Richard S; Kaczmarek, Leonard K; Berde, Charles B; Yu, Timothy W

Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial.

Nous-209 新抗原疫苗用于预防林奇综合征携带者的癌症:一项 1b/2 期试验。

D'Alise Anna Morena, Willis Jason, Duzagac Fahriye, Hall Michael J, Cruz-Correa Marcia, Idos Gregory E, Thirumurthi Selvi, Ballester Veroushka, Leoni Guido, Garzia Irene, Antonucci Laura, De Marco Lorenzo, Micarelli Elisa, Deng Nan, Seclì Laura, Gogov Sven, Dong Wenli, Jack Lee J, Bowen Charles M, Vornik Lana A, Garcia-Gonzalez Araceli, Reyes-Uribe Laura, Richmond Ellen, Umar Asad, Brown Powel H, Sinha Krishna M, Rodriguez Luz Maria, Scarselli Elisa, Vilar Eduardo

Atomically accurate de novo design of antibodies with RFdiffusion

利用射频扩散技术进行原子级精确的抗体从头设计

Bennett, Nathaniel R; Watson, Joseph L; Ragotte, Robert J; Borst, Andrew J; See, DéJenaé L; Weidle, Connor; Biswas, Riti; Yu, Yutong; Shrock, Ellen L; Ault, Russell; Leung, Philip J Y; Huang, Buwei; Goreshnik, Inna; Tam, John; Carr, Kenneth D; Singer, Benedikt; Criswell, Cameron; Wicky, Basile I M; Vafeados, Dionne; Garcia Sanchez, Mariana; Kim, Ho Min; Vázquez Torres, Susana; Chan, Sidney; Sun, Shirley M; Spear, Timothy T; Sun, Yi; O'Reilly, Keelan; Maris, John M; Sgourakis, Nikolaos G; Melnyk, Roman A; Liu, Chang C; Baker, David

IGSF11-VISTA is a critical and targetable immune checkpoint axis in diffuse midline glioma.

IGSF11-VISTA 是弥漫性中线胶质瘤中一个关键且可靶向的免疫检查点轴。

Collot Raphaël, Ruiz-Moreno Cristian, Honhoff Celina, van den Broek Thijs J M, Wezenaar Amber K L, Kloosterman Daan J, Ariese Hendrikus C R, Johnson Hannah, Vervoort Britt M T, Jeiroshi Amal, Bunt Jens, van Ineveld Ravian L, Bokobza Emma, Rebel Heggert G, Te Pas Brigit M, Ringnalda Femke C A, van de Wetering Marc, Robe Pierre A, Kool Marcel, Cochran Jennifer R, Kranendonk Mariëtte E G, van Vuurden Dannis G, Hulleman Esther, Wehrens Ellen J, Zomer Anoek, Stunnenberg Hendrik G, Rios Anne C

Multiple myeloma risk linked to DNA damage response genes

多发性骨髓瘤风险与DNA损伤反应基因相关

Conry, Michael; Ostrovnaya, Irina; Kemel, Yelena; Sinha, Saloni; Baughn, Linda B; Avery, Brian; Maclachlan, Kylee; Groner, Victoria; Banaszak, Lauren; Norman, Aaron; Boddicker, Nicholas J; Clay-Gilmour, Alyssa; Kumar, Shaji; Kim, Ellen; Dandiker, Sita; Waghmare, Mitul; Slager, Susan; Sborov, Douglas W; Garber, Judy; Brown, Elizabeth E; Hildebrandt, Michelle; Hari, Parameshwaran; Camp, Nicola; Vachon, Celine; Usmani, Saad; Offit, Kenneth; Joseph, Vijai

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis

大规模外显子组分析揭示了肌萎缩侧索硬化症中新的罕见变异贡献

Hop, Paul J; Kooyman, Maarten; Kenna, Brendan J; Zwamborn, Ramona A J; van Eijk, Kristel R; Wang, Yan; van Dijk, Charlotte H; Bekema, Erwin; van Rheenen, Wouter; Beele, Paul; van Vugt, Joke J F A; Khleifat, Ahmad Al; Iacoangeli, Alfredo; Cooper-Knock, Johnathan; Smith, Bradley N; Topp, Simon; van der Kooi, Anneke J; Fominykh, Vera; Drory, Vivian; Lerner, Yossef; Shovman, Yehuda; Rowe, Dominic B; Williams, Kelly L; McLaughlin, Russell L; Hurt, Jessica; Huang, Yunfeng; Chen, Chia-Yen; Tsai, Ellen; Runz, Heiko; Aronica, Eleonora; Groen, Ewout J N; van Es, Michael A; Pasterkamp, R Jeroen; Farhan, Sali M K; Garton, Fleur C; McRae, Allan F; McCombe, Pamela A; Henderson, Robert D; Fan, Dongsheng; Šlachtová, Lenka; Høyer, Helle; Nishimura, Agnes L; Cauchi, Ruben J; Brylev, Lev; Rogelj, Boris; Koritnik, Blaž; Zidar, Janez; Salas, Teresa; Mora Pardina, Jesus S; Gotkine, Marc; Povedano, Monica; Corcia, Philippe; Vourc'h, Patrick; Couratier, Philippe; Weber, Markus; Kiernan, Matthew C; Pamphlett, Roger; Blair, Ian P; de Carvalho, Mamede; Başak, Nazli A; Ingre, Caroline; Andersen, Peter M; Zinman, Lorne; Rogaeva, Ekaterina; MacKenzie, Ian R; Dupre, Nicolas; Rouleau, Guy A; Traynor, Bryan J; Ticozzi, Nicola; Chiò, Adriano; Silani, Vincenzo; Hardiman, Orla; Phatnani, Hemali; Harms, Matthew B; Dalgard, Clifton L; Glass, Jonathan D; Landers, John E; Van Damme, Philip; Morrison, Karen E; Shaw, Pamela J; Shaw, Chris E; Al-Chalabi, Ammar; van den Berg, Leonard H; Kenna, Kevin P; Veldink, Jan H

De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell function.

在人脑干类器官中构建新生 H3.3K27M 改变的弥漫性中线胶质瘤,以解析 GD2 CAR T 细胞功能。

Bessler Nils, Wezenaar Amber K L, Ariese Hendrikus C R, Honhoff Celina, Dommann Noëlle, Wehrens Ellen J, Ruiz Moreno Cristian, van den Broek Thijs J M, Collot Raphaël V U, Kloosterman Daan J, Keramati Farid, Roosen Mieke, de Blank Sam, van Vliet Esmée, Barrera Román Mario, Gatti Lucrezia C D E, Ertürk Ali, Kuball Jürgen, Sebestyén Zsolt, Kool Marcel, Patrizi Sara, Miele Evelina, Künkele Annette, Kranendonk Mariëtte E G, Cornel Annelisa M, Nierkens Stefan, Mayer Christian, Stunnenberg Hendrik G, Alemany Anna, Alieva Maria, Rios Anne C

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.

成纤维细胞 TGFβ 信号的空间模式是类风湿性关节炎治疗耐药性的根本原因。

Bhamidipati Kartik, McIntyre Alexa B R, Kazerounian Shideh, Ce Gao, Wong Soon W, Tran Miles, Prell Sean A, Lau Rachel, Khedgikar Vikram, Altmann Christopher, Small Annabelle, Madhu Roopa, Presti Sonia R, Anufrieva Ksenia S, Blazar Philip E, Lange Jeffrey K, Seifert Jennifer A, Moreland Larry W, Croft Adam P, Smith Melanie H, Donlin Laura T, Lewis Myles J, Jonsson Anna H, Pitzalis Costantino, Thomas Ranjeny, Gravallese Ellen M, Brenner Michael B, Korsunsky Ilya, Wechalekar Mihir D, Wei Kevin

Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo.

可扩展的 TCR 合成和筛选能够绘制白癜风中的抗原反应图谱。

Gaglione Stephanie A, Mukkamala Rachit S, Krishna Chirag, Smith Blake E, Wadsworth Marc H 2nd, Jelinsky Scott A, Perez Caleb R, Schmidt-Hong Laura, Katz Erica L, Gellatly Kyle J, Ali Lestat R, Shen Jiao, Holec Patrick V, Zhao Qingyang Henry, Chan Amanda O, Xu Ellen J K, Kravarik Kellie M, Guzova Julia A, Dobson Connor S, Singh Harshabad, Garber Manuel, Dougan Michael, Dougan Stephanie K, Harris John E, Winkler Aaron, Birnbaum Michael E