日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors

SPP1 的鉴定和药理学概况,SPP1 是一种强效、功能选择性和脑渗透性毒蕈碱 M1 受体激动剂

Lisa M Broad, Helen E Sanger, Adrian J Mogg, Ellen M Colvin, Ruud Zwart, David A Evans, Francesca Pasqui, Emanuele Sher, Graham N Wishart, Vanessa N Barth, Christian C Felder, Paul J Goldsmith

In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography

LSN3172176 是一种新型 M1 选择性毒蕈碱受体激动剂示踪分子,可用于正电子发射断层扫描,本文对其进行了体外药理学表征和体内验证。

Adrian J Mogg ,Thomas Eessalu ,Megan Johnson ,Rebecca Wright ,Helen E Sanger ,Hongling Xiao ,Michael G Crabtree ,Alex Smith ,Ellen M Colvin ,Douglas Schober ,Donald Gehlert ,Cynthia Jesudason ,Paul J Goldsmith ,Michael P Johnson ,Christian C Felder ,Vanessa N Barth ,Lisa M Broad

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus

毒蕈碱型 M1 乙酰胆碱受体的激活会诱发海马的长期增强

Siobhan H Dennis, Francesca Pasqui, Ellen M Colvin, Helen Sanger, Adrian J Mogg, Christian C Felder, Lisa M Broad, Steve M Fitzjohn, John T R Isaac, Jack R Mellor