日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons

DNA损伤会导致神经元出现一种独特的、与阿尔茨海默病相关的衰老状态。

Hughes, Jun-Wei B; Sandholm, Anja; Croll, Duncan; Senchyna, Fiona; Schneider, Kevin; Butterfield, Rachel; McHugh, Tyne L M; Brown, Ian; Deguchi, Hideto; Hilsabeck, Tyler A U; Mak, Sally; Wilson, Kenneth A; Davtyan, Hayk; Blurton-Jones, Mathew; Herdy, Joseph; Higuchi-Sanabria, Ryo; Gage, Fred H; Furman, David; Ellerby, Lisa M; Desprez, Pierre-Yves; Campisi, Judith

Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction.

神经元糖原分解通过磷酸戊糖途径介导的氧化应激减少来减轻 tau 蛋白病。

Bar Sudipta, Wilson Kenneth A, Hilsabeck Tyler A U, Alderfer Sydney, Dammer Eric B, Burton Jordan B, Shah Samah, Holtz Anja, Carrera Enrique M, Beck Jennifer N, Chen Jackson H, Kauwe Grant, Seifar Fatemeh, Shantaraman Ananth, Tracy Tara E, Seyfried Nicholas T, Schilling Birgit, Ellerby Lisa M, Kapahi Pankaj

Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan

降低糖化的化合物通过抑制胃饥饿素信号传导来减少食物摄入、降低胰岛素抵抗并延长寿命。

Wimer, Lauren A; Kaneshiro, Kiyomi R; Ramirez, Jessica; Bose, Neelanjan; Valdearcos, Martin; Shanmugam, Muniesh Muthaiyan; Farrera, Dominique O; Singh, Parminder; Beck, Jennifer; Sellegounder, Durai; Najera, Lizbeth Enqriquez; Melov, Simon; Ellerby, Lisa M; Cho, Soo-Jin; Newman, John C; Koliwad, Suneil; Galligan, James J; Kapahi, Pankaj

Cerulenin partially corrects the disrupted developmental transcriptomic signature in Huntington's disease striatal medium spiny neurons.

塞鲁宁可部分纠正亨廷顿病纹状体中型棘状神经元发育转录组特征的紊乱

Galicia Aguirre Carlos, Tshilenge Kizito-Tshitoko, Battistoni Elena, Lopez-Ramirez Alejandro, Naphade Swati, Perez Kevin, Gerencser Akos A, Song Sicheng, Mooney Sean D, Melov Simon, Ehrlich Michelle E, Ellerby Lisa M

Biochemical, structural, and cellular characterization of S-but-3-yn-2-ylglycine as a mechanism-based covalent inactivator of the flavoenzyme proline dehydrogenase

对S-丁-3-炔-2-基甘氨酸作为黄素酶脯氨酸脱氢酶的机制性共价失活剂的生化、结构和细胞表征

Meeks, Kaylen R; Ji, Juan; Scott, Gary K; Campbell, Ashley C; Nix, Jay C; Tadeo, Ada; Ellerby, Lisa M; Benz, Christopher C; Tanner, John J

Uncovering senescent fibroblast heterogeneity connects DNA damage response to idiopathic pulmonary fibrosis

揭示衰老成纤维细胞的异质性将DNA损伤反应与特发性肺纤维化联系起来

Hughes, Jun-Wei B; Pujari, Akshay; Sandholm, Anja; Croll, Duncan; Monk, Lea B; Joshua, Isaac; Butterfield, Rachel; Horton, Cory; Schneider, Kevin; Senchyna, Fiona; Brown, Ian; Coelho, Ana L; Ho, Tsung-Che; Deguchi, Hideto; Le Saux, Claude Jordan; Deinhardt-Emmer, Stefanie; Ellerby, Lisa M; Vitari, Alberto; Furman, David; Hogoboam, Cory M; Laslavic, Alex; Desprez, Pierre-Yves; Quarta, Marco; Campisi, Judith

Investigation of Neurons and Microglia from APOE3 Induced Pluripotent Stem Cells using Data-Independent Acquisitions on a ZenoTOF 7600

利用 ZenoTOF 7600 上的数据非依赖性采集技术研究 APOE3 诱导多能干细胞中的神经元和小胶质细胞

Burton, Jordan B; McHugh, Tyne; Schurman, Charles A; Bons, Joanna; Sanchez, Maria; Ellerby, Lisa M; Schilling, Birgit

Alzheimer's disease risk factor APOE4 exerts dimorphic effects on female bone

阿尔茨海默病风险因素APOE4对女性骨骼具有二态性影响

Schurman, Charles A; Kaur, Gurcharan; Kaya, Serra; Bons, Joanna; Aguirre, Carlos Galicia; Liu, Qi; King, Christina D; Wilson, Kenneth A; Baker, Harrison L; Hady, Mikayala; Luna, Nadja Maldonado; Bieri, Gregor; Villeda, Saul A; Ellerby, Lisa M; Schilling, Birgit; Alliston, Tamara

Twenty years of therapeutic development in tauopathy mouse models: a scoping review

二十年来tau蛋白病小鼠模型治疗进展:一项范围综述

Langness, Vanessa F; Simmons, Danielle A; McHugh, Tyne L M; Butler, Robert R 3rd; Zhou, James; Liu, Harry; Yang, Tao; Ellerby, Lisa M; Longo, Frank M

Huntingtin preserves mitochondrial genome integrity in neurons, which is impaired in Huntington's disease.

亨廷顿蛋白能够维持神经元中线粒体基因组的完整性,而亨廷顿病会损害这种完整性

Pradhan Subrata, Gaikwad Sagar, Tsai Chi-Lin, Smith Charlene, Zhang Nan, Bush Keegan, Chakraborty Anirban, Yuan Subo, Choudhary Sanjeev, Keene C Dirk, Ellerby Lisa M, Hazra Tapas K, La Spada Albert R, Wairkar Yogesh P, Ashizawa Tatsuo, Tainer John A, Pandita Tej K, Thompson Leslie M, Sarkar Partha S