日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet

高剂量二甲双胍与SIRT1激活剂SRT1720联合使用会缩短高脂饮食喂养的老年小鼠的寿命。

Palliyaguru, Dushani L; Minor, Robin K; Mitchell, Sarah J; Palacios, Hector H; Licata, Jordan J; Ward, Theresa M; Abulwerdi, Gelareh; Elliott, Peter; Westphal, Christoph; Ellis, James L; Sinclair, David A; Price, Nathan L; Bernier, Michel; de Cabo, Rafael

Sirtuin activators and inhibitors: Promises, achievements, and challenges

Sirtuin激活剂和抑制剂:前景、成就与挑战

Dai, Han; Sinclair, David A; Ellis, James L; Steegborn, Clemens

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

Sirt1激活剂SRT3025通过减少肝脏Pcsk9分泌和增强Ldlr表达,在Apoe-/-小鼠中发挥抗动脉粥样硬化作用。

Miranda, Melroy X; van Tits, Lambertus J; Lohmann, Christine; Arsiwala, Tasneem; Winnik, Stephan; Tailleux, Anne; Stein, Sokrates; Gomes, Ana P; Suri, Vipin; Ellis, James L; Lutz, Thomas A; Hottiger, Michael O; Sinclair, David A; Auwerx, Johan; Schoonjans, Kristina; Staels, Bart; Lüscher, Thomas F; Matter, Christian M

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

SIRT1激活剂SRT1720可延长喂食标准饲料的小鼠的寿命并改善其健康状况。

Mitchell, Sarah J; Martin-Montalvo, Alejandro; Mercken, Evi M; Palacios, Hector H; Ward, Theresa M; Abulwerdi, Gelareh; Minor, Robin K; Vlasuk, George P; Ellis, James L; Sinclair, David A; Dawson, John; Allison, David B; Zhang, Yongqing; Becker, Kevin G; Bernier, Michel; de Cabo, Rafael

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Sirtuin 1 激活剂 SRT2104 可保护亨廷顿病小鼠

Jiang, Mali; Zheng, Jennifer; Peng, Qi; Hou, Zhipeng; Zhang, Jiangyang; Mori, Susumu; Ellis, James L; Vlasuk, George P; Fries, Harvey; Suri, Vipin; Duan, Wenzhen

Identification of a SIRT1 mutation in a family with type 1 diabetes.

在患有 1 型糖尿病的家族中鉴定出 SIRT1 基因突变

Biason-Lauber Anna, Böni-Schnetzler Marianne, Hubbard Basil P, Bouzakri Karim, Brunner Andrea, Cavelti-Weder Claudia, Keller Cornelia, Meyer-Böni Monika, Meier Daniel T, Brorsson Caroline, Timper Katharina, Leibowitz Gil, Patrignani Andrea, Bruggmann Remy, Boily Gino, Zulewski Henryk, Geier Andreas, Cermak Jennifer M, Elliott Peter, Ellis James L, Westphal Christoph, Knobel Urs, Eloranta Jyrki J, Kerr-Conte Julie, Pattou François, Konrad Daniel, Matter Christian M, Fontana Adriano, Rogler Gerhard, Schlapbach Ralph, Regairaz Camille, Carballido José M, Glaser Benjamin, McBurney Michael W, Pociot Flemming, Sinclair David A, Donath Marc Y

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

羧酰胺类SIRT1抑制剂通过一种不依赖于乙酰化的机制阻断DBC1结合。

Hubbard, Basil P; Loh, Christine; Gomes, Ana P; Li, Jun; Lu, Quinn; Doyle, Taylor Lg; Disch, Jeremy S; Armour, Sean M; Ellis, James L; Vlasuk, George P; Sinclair, David A

SRT1720 improves survival and healthspan of obese mice

SRT1720 可提高肥胖小鼠的存活率和健康寿命

Minor, Robin K; Baur, Joseph A; Gomes, Ana P; Ward, Theresa M; Csiszar, Anna; Mercken, Evi M; Abdelmohsen, Kotb; Shin, Yu-Kyong; Canto, Carles; Scheibye-Knudsen, Morten; Krawczyk, Melissa; Irusta, Pablo M; Martín-Montalvo, Alejandro; Hubbard, Basil P; Zhang, Yongqing; Lehrmann, Elin; White, Alexa A; Price, Nathan L; Swindell, William R; Pearson, Kevin J; Becker, Kevin G; Bohr, Vilhelm A; Gorospe, Myriam; Egan, Josephine M; Talan, Mark I; Auwerx, Johan; Westphal, Christoph H; Ellis, James L; Ungvari, Zoltan; Vlasuk, George P; Elliott, Peter J; Sinclair, David A; de Cabo, Rafael