P2RX7 deficiency prevents cognitive deficit, brain atrophy and tauopathy progression in PS19 mice via suppression of extracellular vesicle secretion and mitochondrial toxicity
P2RX7 缺陷通过抑制细胞外囊泡分泌和线粒体毒性,阻止 PS19 小鼠出现认知缺陷、脑萎缩和 tau 蛋白病变进展。
期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0323769
Baker, Emily; Leonenko, Ganna; Schmidt, Karl Michael; Hill, Matthew; Myers, Amanda J; Shoai, Maryam; de Rojas, Itziar; Tesi, Niccoló; Holstege, Henne; van der Flier, Wiesje M; Pijnenburg, Yolande A L; Ruiz, Agustin; Hardy, John; van der Lee, Sven; Escott-Price, Valentina; Borna, Sahar; Gomez-Cabello, Cesar A; Ali Haider, Syed; Genovese, Ariana; Prabha, Srinivasagam; Trabilsy, Maissa; Haider, Clifton R; Felton, Christopher L; Carter, Rickey E; McLeod, Christopher J; Bruce, Charles J; Jorge Forte, Antonio; WANG, NA; Doss, Sydney V; Chang, Yuzhou; Tauer, William; Ren, Yingxue; Qi, Fangfang; Bu, Guojun; Liu, Chia‐Chen; Wu, Long‐Jun; Santos, Victor B; Abdullah, Mohammad; Ellison, Justice; Ruan, Zhi; Ikezu, Tsuneya; Ikezu, Seiko