日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer's disease.

APOE4 人类大脑来源的细胞外囊泡中独特的脂质货物可募集细胞粘附分子,并促进阿尔茨海默病中的 tau 蛋白病变

Ikezu Tsuneya, Zhang Zhengrong, Yu Kaiwen, Bao Hanmei, Ikezu Tadafumi, Ravula Arun Reddy, Melvin Bridgette, Scholes Clara, You Yang, Ellison Justice, Kanekiyo Takahisa, Wszolek Zbigniew, DeTure Michael, Dickson Dennis, Han Xianlin, Peng Junmin, Ikezu Seiko

P2RX7 regulates tauopathy progression via tau and mitochondria loading in extracellular vesicles.

P2RX7 通过细胞外囊泡中 tau 蛋白和线粒体的装载来调节 tau 蛋白病的进展

Ikezu Tsuneya, Bodart-Santos Victor, Ravula Arun Reddy, You Yang, Abdullah Mohammad, Ruan Zhi, Ellison Justice, Radhakishun Stephanie, Ray Nibedita Basu, Melvin Bridgette, Kurti Aishe, Liang Zhewei, Sakai Yuta, O'Brien Daniel, Nguyen Son, Shaffer Scott, Fiddes Lindsey, Butovsky Oleg, Springer Wolfdieter, Ikezu Seiko

P2RX7 deficiency prevents cognitive deficit, brain atrophy and tauopathy progression in PS19 mice via suppression of extracellular vesicle secretion and mitochondrial toxicity

P2RX7 缺陷通过抑制细胞外囊泡分泌和线粒体毒性,阻止 PS19 小鼠出现认知缺陷、脑萎缩和 tau 蛋白病变进展。

Baker, Emily; Leonenko, Ganna; Schmidt, Karl Michael; Hill, Matthew; Myers, Amanda J; Shoai, Maryam; de Rojas, Itziar; Tesi, Niccoló; Holstege, Henne; van der Flier, Wiesje M; Pijnenburg, Yolande A L; Ruiz, Agustin; Hardy, John; van der Lee, Sven; Escott-Price, Valentina; Borna, Sahar; Gomez-Cabello, Cesar A; Ali Haider, Syed; Genovese, Ariana; Prabha, Srinivasagam; Trabilsy, Maissa; Haider, Clifton R; Felton, Christopher L; Carter, Rickey E; McLeod, Christopher J; Bruce, Charles J; Jorge Forte, Antonio; WANG, NA; Doss, Sydney V; Chang, Yuzhou; Tauer, William; Ren, Yingxue; Qi, Fangfang; Bu, Guojun; Liu, Chia‐Chen; Wu, Long‐Jun; Santos, Victor B; Abdullah, Mohammad; Ellison, Justice; Ruan, Zhi; Ikezu, Tsuneya; Ikezu, Seiko