日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

REACtiVe-2: phase I evaluation of dendritic cell vaccination and agonistic CD40 therapy following (m)FOLFIRINOX in metastatic pancreatic cancer

REACTiVe-2:转移性胰腺癌患者接受 (m)FOLFIRINOX 方案治疗后,树突状细胞疫苗接种和激动性 CD40 疗法的 I 期评估

Songul Kucukcelebi # ,Freek R van 't Land # ,Sjoerd H van der Burg ,Ferry A L M Eskens ,Marjolein Y V Homs ,Marcella Willemsen ,Anne Onrust-van Schoonhoven ,Nina E M Rozendaal ,Amine Fellah ,Disha Vadgama ,Miranda Moskie ,Koen Bezemer ,Michail Doukas ,Casper W F van Eijck ,Ralph Stadhouders ,Judith de Vos-Geelen ,Aniek E van Diepen ,Ilona Enninga ,Rob Meijer ,Sumeet V Ambarkhane ,Peter Ellmark ,Joachim G J V Aerts ,Christianne Groeneveldt ,Casper H J van Eijck

CD40 agonist mitazalimab with mFOLFIRINOX in untreated metastatic pancreatic cancer: Biomarkers associated with outcomes from OPTIMIZE-1

CD40激动剂mitazalimab联合mFOLFIRINOX方案治疗未经治疗的转移性胰腺癌:OPTIMIZE-1研究中与疗效相关的生物标志物

Jean-Luc Van Laethem ,Karen Geboes ,Ivan Borbath ,Teresa Macarulla Mercade ,Aurélien Lambert ,Philippe Cassier ,Hans Prenen ,Emmanuel Mitry ,Jean-Frédéric Blanc ,Lorenzo Pilla ,Jaime Feliu ,Mercedes Rodriguez Garrote ,Roberto Antonio Pazo-Cid ,Inmaculada Gallego ,Karin Enell Smith ,Karin Nordbladh ,David Gomez Jimenez ,Peter Ellmark ,Yago Pico de Coaña ,Sumeet Vijay Ambarkhane ,Gregory L Beatty ,Eileen M O'Reilly

First-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignancies

首次人体试验、多中心、开放标签的 I 期研究,评估 ATOR-1017(evunzekibart,一种 4-1BB 抗体)在晚期实体恶性肿瘤患者中的疗效

Carneiro, Ana; Hahn, Amanda; Ellmark, Peter; Enell Smith, Karin; Schultz, Lena; Ambarkhane, Sumeet; Yachnin, Jeffrey; Ullenhag, Gustav J

ATOR-4066, a Bispecific Antibody Targeting CD40 and CEACAM5, Induces Strong Myeloid and T Cell-Dependent Tumor Immunity and Synergizes with PD-1 Blockade

ATOR-4066 是一种靶向 CD40 和 CEACAM5 的双特异性抗体,可诱导强烈的髓系和 T 细胞依赖性肿瘤免疫,并与 PD-1 阻断剂产生协同作用。

Hampus Andersson ,Ida Uddbäck ,Tova Hermodsson ,Mona Celander ,Amulya Krishna Shetty ,Lill Ljung ,Anneli Nilsson ,Anette Sundstedt ,Laura von Schantz ,Laura A Varas ,Mattias Levin ,Anna Säll ,Dietmar Weilguny ,Kim Jansson ,Sara Fritzell ,Karin Hägerbrand ,Malin Lindstedt # ,Peter Ellmark #

Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platform.

利用基于 CD40 卷曲螺旋亲和力的平台将抗原肽递送至抗原呈递细胞

Nyesiga Barnabas, Hägerbrand Karin, Varas Laura, Gjörloff Wingren Anette, Ohlin Mats, Ellmark Peter, von Schantz Laura

Distinct Infiltration of T Cell Populations in Bladder Cancer Molecular Subtypes

膀胱癌分子亚型中T细胞群的浸润特征

Sincic, Viktor; Arlenhold, Ken F; Richtmann, Sarah; Lilljebjörn, Henrik; Eriksson, Pontus; Sjödahl, Gottfrid; Wokander, Mats; Hägerbrand, Karin; Ellmark, Peter; Fioretos, Thoas; Borrebaeck, Carl A K; Liedberg, Fredrik; Lundberg, Kristina

ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1

ATOR-1017 (evunzekibart) 是一种 Fc-γ 受体条件性 4-1BB 激动剂,旨在实现最佳安全性和有效性,与抗 PD-1 联合使用可激活耗竭的 T 细胞

Karin Enell Smith #, Sara Fritzell #, Anneli Nilsson, Karin Barchan, Anna Rosén, Lena Schultz, Laura Varas, Anna Säll, Nadia Rose, Maria Håkansson, Laura von Schantz, Peter Ellmark

Transcriptional profiling demonstrates altered characteristics of CD8+ cytotoxic T-cells and regulatory T-cells in TP53-mutated acute myeloid leukemia

转录组分析表明,TP53突变型急性髓系白血病中CD8+细胞毒性T细胞和调节性T细胞的特征发生了改变。

Milad Abolhalaj ,Viktor Sincic ,Henrik Lilljebjörn ,Carl Sandén ,Alar Aab ,Karin Hägerbrand ,Peter Ellmark ,Carl A K Borrebaeck ,Thoas Fioretos ,Kristina Lundberg

CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

CD137 (4-1BB) 对 CD8+ T 细胞的共刺激作用,在顺式而非反式条件下对 CD3-TCR 刺激更为有效。

Itziar Otano # ,Arantza Azpilikueta # ,Javier Glez-Vaz ,Maite Alvarez ,José Medina-Echeverz ,Ivan Cortés-Domínguez ,Carlos Ortiz-de-Solorzano ,Peter Ellmark ,Sara Fritzell ,Gabriela Hernandez-Hoyos ,Michelle Hase Nelson ,María Carmen Ochoa ,Elixabet Bolaños ,Doina Cuculescu ,Patricia Jaúregui ,Sandra Sanchez-Gregorio ,Iñaki Etxeberria ,María E Rodriguez-Ruiz ,Miguel F Sanmamed ,Álvaro Teijeira ,Pedro Berraondo ,Ignacio Melero

The human anti-CD40 agonist antibody mitazalimab (ADC-1013; JNJ-64457107) activates antigen-presenting cells, improves expansion of antigen-specific T cells, and enhances anti-tumor efficacy of a model cancer vaccine in vivo

人类抗 CD40 激动剂抗体米塔扎利单抗 (ADC-1013; JNJ-64457107) 可激活抗原呈递细胞、促进抗原特异性 T 细胞扩增并增强模型癌症疫苗在体内的抗肿瘤功效

Adnan Deronic, Anneli Nilsson, Mia Thagesson, Doreen Werchau, Karin Enell Smith, Peter Ellmark