日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes.

基于深度学习的从头发现和设计能够逆转疾病相关转录表型的治疗方法。

Xing Jing, Tan Mingdian, Leshchiner Dmitry, Sun Mengying, Abdelgied Mohamed, Huang Li, Paithankar Shreya, Uhl Katie, Shankar Rama, Lisabeth Erika, Aleiwi Bilal, Jager Tara, Lawson Cameron, Chen Ruoqiao, Giletto Matthew, Girgis Reda, Neubig Richard R, So Samuel, Ellsworth Edmund, Li Xiaopeng, Chua Mei-Sze, Zhou Jiayu, Chen Bin

Defining the Mechanism of Action and Resistance of New Mycobacterium abscessus MmpL3 Inhibitors

阐明新型脓肿分枝杆菌MmpL3抑制剂的作用机制和耐药性

Abdalla, Bassel J; Giletto, Matthew B; Goksel Carpa, Nazli; Wilson, Angela K; Ellsworth, Edmund; Abramovitch, Robert B

Design, Synthesis, and Biological Activity of Novel Ornithine Decarboxylase (ODC) Inhibitors

新型鸟氨酸脱羧酶(ODC)抑制剂的设计、合成及生物活性

Schultz, Chad R; Aleiwi, Bilal; Zhou, X Edward; Suino-Powell, Kelly; Melcher, Karsten; Almeida, Nuno M S; Wilson, Angela K; Ellsworth, Edmund L; Bachmann, André S

The RXR Agonist MSU-42011 Reduces Tumor Burden in a Murine Preclinical NF1-Deficient Model.

RXR激动剂MSU-42011可降低小鼠临床前NF1缺陷模型中的肿瘤负荷

Hung Pei-Yu, Moerland Jessica A, Leal Ana S, Aleiwi Bilal, Ellsworth Edmund, Clapp D Wade, Staedtke Verena, Bai Renyuan, Liby Karen T

The Mycobacterium tuberculosis MmpL3 inhibitor MSU-43085 is active in a mouse model of infection

结核分枝杆菌MmpL3抑制剂MSU-43085在小鼠感染模型中具有活性。

Williams, John T; Giletto, Matthew; Haiderer, Elizabeth R; Aleiwi, Bilal; Krieger-Burke, Teresa; Ellsworth, Edmund; Abramovitch, Robert B

Machine Learning Analysis of Cocaine Addiction Informed by DAT, SERT, and NET-Based Interactome Networks

基于DAT、SERT和NET互作组网络的机器学习分析可卡因成瘾

Feng, Hongsong; Gao, Kaifu; Chen, Dong; Shen, Li; Robison, Alfred J; Ellsworth, Edmund; Wei, Guo-Wei

Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme

通过靶向反应调节因子DNA结合和传感器激酶血红素来抑制结核分枝杆菌DosRST信号通路。

Zheng, Huiqing; Williams, John T; Aleiwi, Bilal; Ellsworth, Edmund; Abramovitch, Robert B

Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance

通过非靶向和靶向突变筛选鉴定新的MmpL3抑制剂,并确定具有差异耐药性的MmpL3结构域。

Williams, John T; Haiderer, Elizabeth R; Coulson, Garry B; Conner, Kayla N; Ellsworth, Edmund; Chen, Chao; Alvarez-Cabrera, Nadine; Li, Wei; Jackson, Mary; Dick, Thomas; Abramovitch, Robert B

Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis

深渊霉素综述:绒毛酸途径和叶酸生物合成抑制剂

Sadaka, Carmen; Ellsworth, Edmund; Hansen, Paul Robert; Ewin, Richard; Damborg, Peter; Watts, Jeffrey L