日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Distinct genetic architecture of gene and isoform level QTL in the Diversity Outbred (DO) mouse population

多样性近交系(DO)小鼠群体中基因和亚型水平QTL的独特遗传结构

Opara, Charles I; Mitok, Kelly A; Emfinger, Christopher H; Schueler, Katheryn L; Stapleton, Donnie S; Benkusky, Nancy A; Gardiparthi, Udaya; Willis, Kalynn H; Ruotti, Victor; Yandell, Brian S; Churchill, Gary A; Keller, Mark P; Attie, Alan D

A graph-based learning approach to predict the effects of gene perturbations on molecular phenotypes

一种基于图学习的预测基因扰动对分子表型影响的方法

Jin, Yiyang; Sverchkov, Yuriy; Sushkova, Anastasiya; Ohtake, Michael; Emfinger, Christopher; Craven, Mark

VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells.

VDAC1 是 β 细胞中药物诱导胰岛素过度分泌的靶点

Roy Gitanjali, Ordóñez Andrea, Binns Derk D, Rodrigues-Dos-Santos Karina, Kwakye Michael B, King George C, Kuntz Rachel L, Mukherjee Noyonika, Templin Andrew T, Tan Zhiyong, Richardson Timothy I, Doud Emma H, Mosley Amber L, Schueler Kathryn L, Emfinger Christopher H, Attie Alan D, Keller Mark P, Johnson Travis S, Kalwat Michael A

Genetic Analysis of Obesity-Induced Diabetic Nephropathy in BTBR Mice

BTBR小鼠肥胖诱导糖尿病肾病的遗传分析

Keller, Mark P; O'Connor, Chris; Bitzer, Markus; Schueler, Kathryn L; Stapleton, Donald S; Emfinger, Christopher H; Broman, Aimee Teo; Hodgin, Jeffrey B; Attie, Alan D

Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

从小鼠胰岛 Ca2+ 振荡的遗传变异中鉴定出新的胰岛功能调节剂

Christopher H Emfinger #, Lauren E Clark #, Brian Yandell, Kathryn L Schueler, Shane P Simonett, Donnie S Stapleton, Kelly A Mitok, Matthew J Merrins, Mark P Keller, Alan D Attie

Loss of ZNF148 enhances insulin secretion in human pancreatic β cells

ZNF148 的缺失会增强人类胰腺 β 细胞的胰岛素分泌

Eleonora de Klerk, Yini Xiao, Christopher H Emfinger, Mark P Keller, David I Berrios, Valentina Loconte, Axel A Ekman, Kate L White, Rebecca L Cardone, Richard G Kibbey, Alan D Attie, Matthias Hebrok

Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population

在多样性近交系小鼠群体中鉴定血浆脂蛋白大小的遗传驱动因素

Price, Tara R; Emfinger, Christopher H; Schueler, Kathryn L; King, Sarah; Nicholson, Rebekah; Beck, Tim; Yandell, Brian S; Summers, Scott A; Holland, William L; Krauss, Ronald M; Keller, Mark P; Attie, Alan D

β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses

β 细胞特异性删除 Zfp148 可改善营养刺激的 β 细胞 Ca2+ 反应

Christopher H Emfinger, Eleonora de Klerk, Kathryn L Schueler, Mary E Rabaglia, Donnie S Stapleton, Shane P Simonett, Kelly A Mitok, Ziyue Wang, Xinyue Liu, Joao A Paulo, Qing Yu, Rebecca L Cardone, Hannah R Foster, Sophie L Lewandowski, José C Perales, Christina M Kendziorski, Steven P Gygi, Richar

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice

基因修饰小鼠中坎图综合征SUR2变异R1154Q的复杂后果

Zhang, Haixia; Hanson, Alex; de Almeida, Tobias Scherf; Emfinger, Christopher; McClenaghan, Conor; Harter, Theresa; Yan, Zihan; Cooper, Paige E; Brown, G Schuyler; Arakel, Eric C; Mecham, Robert P; Kovacs, Atilla; Halabi, Carmen M; Schwappach, Blanche; Remedi, Maria S; Nichols, Colin G

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

ABCC9 相关智力障碍肌病综合征是一种 KATP 通道病,因 ABCC9 功能丧失而发生突变

Marie F Smeland, Conor McClenaghan, Helen I Roessler, Sanne Savelberg, Geir Åsmund Myge Hansen, Helene Hjellnes, Kjell Arne Arntzen, Kai Ivar Müller, Andreas Rosenberger Dybesland, Theresa Harter, Monica Sala-Rabanal, Chris H Emfinger, Yan Huang, Soma S Singareddy, Jamie Gunn, David F Wozniak, Attil