日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain

降低脱落胞外域水平的抗 TREM2 scFv 的选择和结构表征

Aleksandra Szykowska, Yu Chen, Thomas B Smith, Charlotta Preger, Jingjing Yang, Dongming Qian, Shubhashish M Mukhopadhyay, Edvard Wigren, Stephen J Neame, Susanne Gräslund, Helena Persson, Peter J Atkinson, Elena Di Daniel, Emma Mead, John Wang, John B Davis, Nicola A Burgess-Brown, Alex N Bullock

PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages

PLCγ2 调节 TREM2 信号传导和整合素介导的人类 iPSC 衍生巨噬细胞的粘附和迁移

Juliane Obst, Hazel L Hall-Roberts, Thomas B Smith, Mira Kreuzer, Lorenza Magno, Elena Di Daniel, John B Davis, Emma Mead

TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

TREM2 阿尔茨海默病变体 R47H 会导致与基因敲除类似的转录失调,但在人类 iPSC 衍生的巨噬细胞中仅表现出轻微的功能表型。

Hazel Hall-Roberts ,Devika Agarwal ,Juliane Obst ,Thomas B Smith ,Jimena Monzón-Sandoval ,Elena Di Daniel ,Caleb Webber ,William S James ,Emma Mead ,John B Davis ,Sally A Cowley