NMR structures of apo L. casei dihydrofolate reductase and its complexes with trimethoprim and NADPH: contributions to positive cooperative binding from ligand-induced refolding, conformational changes, and interligand hydrophobic interactions

脱辅基乳酸杆菌二氢叶酸还原酶及其与甲氧苄啶和 NADPH 复合物的 NMR 结构：配体诱导的重折叠、构象变化和配体间疏水相互作用对正协同结合的贡献