Prefusion RSV F Immunization Elicits Th2-Mediated Lung Pathology in Mice When Formulated With a Th2 (but Not a Th1/Th2-Balanced) Adjuvant Despite Complete Viral Protection
尽管病毒完全保护,但当使用 Th2 佐剂(而非 Th1/Th2 平衡佐剂)配制融合前 RSV F 免疫时,小鼠仍会诱发 Th2 介导的肺部病理。
期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2020.01673
Eichinger, Katherine M; Kosanovich, Jessica L; Gidwani, Sonal V; Zomback, Aaron; Lipp, Madeline A; Perkins, Timothy N; Oury, Tim D; Petrovsky, Nikolai; Marshall, Christopher P; Yondola, Mark A; Empey, Kerry M