日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combined antagonism of Oncostatin M (OSM) and Interleukin 6 (IL-6) provides both anti-fibrotic and anti-inflammatory benefit in pulmonary fibrosis

联合拮抗抑瘤素M(OSM)和白细胞介素6(IL-6)可同时发挥抗纤维化和抗炎作用,用于治疗肺纤维化。

Ratsimandresy, Rojo A; Doran, Emma; Dengler, Hart S; Headland, Sarah E; Wedeles, Christopher J; Guidi, Riccardo; Xu, Daqi; Liu, Jiatong; Shi, Yongchang; Wang, Jianyong; Uttarwar, Salil; Abbas, Alexander R; Sun, Tianhe; DePianto, Daryle J; Morshead, Katrina B; Arron, Joe; Rock, Jason R; Bevers, Jack; Yadav, Rajbharan; Ramalingam, Thirumalai; Gao, Xia; Brightbill, Hans D; Emson, Claire L; Jeet, Surinder; Arlantico, Alexander; Wong, Aaron; Yu, Sherman; Tran, Tiffany Hao; Leong, Laurie; Dohse, Monika; Austin, Cary; Caplazi, Patrick; Panettieri, Reynold A; Koziol-White, Cynthia; Jester, William F; Shaw, Andrey; Avraham, Shimrit; Menon, Hari; Darmanis, Spyros; Modrusan, Zora; Kajihara, Kimberly; Kanamori, Masakazu; Shimada, Hideaki; West, Nathaniel R; Nakamura, Gerald; Vander Heiden, Jason A; Wilson, Mark S

Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis

溶血磷脂酸受体1抑制:肺纤维化的潜在治疗靶点

Volkmann, Elizabeth R; Denton, Christopher P; Kolb, Martin; Wijsenbeek-Lourens, Marlies S; Emson, Claire; Hudson, Krischan; Amatucci, Anthony J; Distler, Oliver; Allanore, Yannick; Khanna, Dinesh

LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung

LOXL4,而非 LOXL2,是肺病理性胶原交联和纤维化的关键决定因素

Hsiao-Yen Ma, Qingling Li, Weng Ruh Wong, Elsa-Noah N'Diaye, Patrick Caplazi, Hannah Bender, Zhiyu Huang, Alexander Arlantico, Surinder Jeet, Aaron Wong, Claire Emson, Hans Brightbill, Lucinda Tam, Robert Newman, Merone Roose-Girma, Wendy Sandoval, Ning Ding

Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts

不同人群肺功能和1秒用力呼气容积下降的系统性指标

Ngo, Debby; Pratte, Katherine A; Flexeder, Claudia; Petersen, Hans; Dang, Hong; Ma, Yanlin; Keyes, Michelle J; Gao, Yan; Deng, Shuliang; Peterson, Bennet D; Farrell, Laurie A; Bhambhani, Victoria M; Palacios, Cesar; Quadir, Juweria; Gillenwater, Lucas; Xu, Hanfei; Emson, Claire; Gieger, Christian; Suhre, Karsten; Graumann, Johannes; Jain, Deepti; Conomos, Matthew P; Tracy, Russell P; Guo, Xiuqing; Liu, Yongmei; Johnson, W Craig; Cornell, Elaine; Durda, Peter; Taylor, Kent D; Papanicolaou, George J; Rich, Stephen S; Rotter, Jerome I; Rennard, Steven I; Curtis, Jeffrey L; Woodruff, Prescott G; Comellas, Alejandro P; Silverman, Edwin K; Crapo, James D; Larson, Martin G; Vasan, Ramachandran S; Wang, Thomas J; Correa, Adolfo; Sims, Mario; Wilson, James G; Gerszten, Robert E; O'Connor, George T; Barr, R Graham; Couper, David; Dupuis, Josée; Manichaikul, Ani; O'Neal, Wanda K; Tesfaigzi, Yohannes; Schulz, Holger; Bowler, Russell P

Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results

围手术期联合应用拉帕替尼和曲妥珠单抗治疗早期HER2阳性乳腺癌可识别早期应答者:英国EPHOS-B随机试验的长期结果

Bundred, Nigel; Porta, Nuria; Brunt, Adrian Murray; Cramer, Angela; Hanby, Andrew; Shaaban, Abeer M; Rakha, Emad A; Armstrong, Anne; Cutress, Ramsey I; Dodwell, David; Emson, Marie A; Evans, Abigail; Hartup, Sue M; Horgan, Kieran; Miller, Sarah E; McIntosh, Stuart A; Morden, James P; Naik, Jay; Narayanan, Sankaran; Ooi, Jane; Skene, Anthony I; Cameron, David A; Bliss, Judith M

Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma with and without Nasal Polyposis: A Post Hoc Analysis of the Phase 2b PATHWAY Study

Tezepelumab治疗伴或不伴鼻息肉的重度难治性哮喘患者的疗效:PATHWAY 2b期研究的事后分析

Emson, Claire; Corren, Jonathan; Sałapa, Kinga; Hellqvist, Åsa; Parnes, Jane R; Colice, Gene

CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma

CASCADE:一项 II 期随机、双盲、安慰剂对照、平行组试验,旨在评估 tezepelumab 对未控制哮喘患者气道炎症的影响

Emson, Claire; Diver, Sarah; Chachi, Latifa; Megally, Ayman; Small, Cherrie; Downie, John; Parnes, Jane R; Bowen, Karin; Colice, Gene; Brightling, Chris E

Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity

发现具有强效体内活性的苯并内酰胺类IRAK4抑制剂

Rajapaksa, Naomi S; Gobbi, Alberto; Drobnick, Joy; Do, Steven; Kolesnikov, Aleksandr; Liang, Jun; Chen, Yongsheng; Sujatha-Bhaskar, Swathi; Huang, Zhiyu; Brightbill, Hans; Francis, Ross; Yu, Christine; Choo, Edna F; DeMent, Kevin; Ran, Yingqing; An, Le; Emson, Claire; Maher, Jonathan; Wai, John; McKenzie, Brent S; Lupardus, Patrick J; Zarrin, Ali A; Kiefer, James R; Bryan, Marian C

Comparison of Proteomic Assessment Methods in Multiple Cohort Studies

多队列研究中蛋白质组学评估方法的比较

Raffield, Laura M; Dang, Hong; Pratte, Katherine A; Jacobson, Sean; Gillenwater, Lucas A; Ampleford, Elizabeth; Barjaktarevic, Igor; Basta, Patricia; Clish, Clary B; Comellas, Alejandro P; Cornell, Elaine; Curtis, Jeffrey L; Doerschuk, Claire; Durda, Peter; Emson, Claire; Freeman, Christine M; Guo, Xiuqing; Hastie, Annette T; Hawkins, Gregory A; Herrera, Julio; Johnson, W Craig; Labaki, Wassim W; Liu, Yongmei; Masters, Brett; Miller, Michael; Ortega, Victor E; Papanicolaou, George; Peters, Stephen; Taylor, Kent D; Rich, Stephen S; Rotter, Jerome I; Auer, Paul; Reiner, Alex P; Tracy, Russell P; Ngo, Debby; Gerszten, Robert E; O'Neal, Wanda K; Bowler, Russell P

Results of a multicentre randomised controlled trial of cochlear-sparing intensity-modulated radiotherapy versus conventional radiotherapy in patients with parotid cancer (COSTAR; CRUK/08/004)

一项针对腮腺癌患者的耳蜗保护性调强放射治疗与常规放射治疗的多中心随机对照试验结果(COSTAR;CRUK/08/004)

Nutting, Christopher M; Morden, James P; Beasley, Matthew; Bhide, Shreerang; Cook, Audrey; De Winton, Emma; Emson, Marie; Evans, Mererid; Fresco, Lydia; Gollins, Simon; Gujral, Dorothy; Harrington, Kevin; Joseph, Mano; Lemon, Catherine; Luxon, Linda; van den Blink, Qurrat; Mendes, Ruheena; Miah, Aisha; Newbold, Kate; Prestwich, Robin; Robinson, Martin; Sanghera, Paul; Simpson, Joanna; Sivaramalingam, Muthiah; Srihari, Narayanan Nair; Sydenham, Mark; Wells, Emma; Witts, Stephanie; Hall, Emma