日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting Neutrophil-Mediated Inflammation: Identification of Pyrazolidinone Carboxamide Derivatives as Potent Selective Inhibitors of Formyl Peptide Receptor 1 (FPR1)-Activated Neutrophils.

靶向中性粒细胞介导的炎症:鉴定吡唑烷酮羧酰胺衍生物为甲酰肽受体 1 (FPR1) 激活的中性粒细胞的强效选择性抑制剂

Abdel-Halim Mohammad, Wagdy Reem A, Salah Mohamed, Wang Yi-Hsuan, Cheng Tzu-Peng, Lee Yao-Rong, Chen Yu-Cheng, Mandour Yasmine M, Abadi Ashraf H, Engel Matthias, Hwang Tsong-Long

Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways.

发现 1,3-二取代丙-2-烯-1-酮衍生物可通过调节 MAPK 和 Akt 通路抑制中性粒细胞炎症

Abdel-Halim Mohammad, El-Gamil Dalia S, Hammam Mennatallah A, El-Shazly Mohamed, Wang Yi-Hsuan, Kung Po-Hsiung, Chen Yu-Cheng, Korinek Michal, Abadi Ashraf H, Engel Matthias, Hwang Tsong-Long

Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity

开发5-羟基苯并噻吩衍生物作为具有潜在抗癌活性的多激酶抑制剂

Abd El-Rahman, Yara A; Chen, Po-Jen; ElHady, Ahmed K; Chen, Shun-Hua; Lin, Hsin-Chieh; El-Gamil, Dalia S; Aboushady, Youssef; Abadi, Ashraf H; Engel, Matthias; Abdel-Halim, Mohammad

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

结肠肿瘤细胞死亡通过旁分泌 P2X4 刺激引起 mTOR 依赖

Mark Schmitt, Fatih Ceteci #, Jalaj Gupta #, Marina Pesic, Tim W Böttger, Adele M Nicolas, Kilian B Kennel, Esther Engel, Matthias Schewe, Asude Callak Kirisözü, Valentina Petrocelli, Yasamin Dabiri, Julia Varga, Mallika Ramakrishnan, Madina Karimova, Andrea Ablasser, Toshiro Sato, Melek C Arkan, Fr

HiatoGast 1: an exploring, semiblinded trial establishing a new endoscopical categorisation of axial hiatal hernias

HiatoGast 1:一项探索性、半盲试验,旨在建立一种新的轴型食管裂孔疝内镜分类方法

Eckhardt, Daniel; Engel, Matthias A; Golcher, Henriette; Krautz, Christian; Grützmann, Robert; Elshafei, Moustafa

Neuro-Immune Networks in Gastrointestinal Disorders

胃肠道疾病中的神经免疫网络

Khalil, Mohammad; Zhang, Zehua; Engel, Matthias A

Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia

瞬时受体电位通道在免疫细胞和上皮细胞中的功能作用

Khalil, Mohammad; Alliger, Korina; Weidinger, Carl; Yerinde, Cansu; Wirtz, Stefan; Becker, Christoph; Engel, Matthias Agop

Design and synthesis of conformationally constraint Dyrk1A inhibitors by creating an intramolecular H-bond involving a benzothiazole core

通过构建涉及苯并噻唑核心的分子内氢键,设计并合成构象受限的Dyrk1A抑制剂

Salah, Mohamed; Abdel-Halim, Mohammad; Engel, Matthias

Design and synthesis of novel 1,3,5-triphenyl pyrazolines as potential anti-inflammatory agents through allosteric inhibition of protein kinase Czeta (PKCζ)

通过变构抑制蛋白激酶Cζ(PKCζ)设计合成新型1,3,5-三苯基吡唑啉类化合物作为潜在的抗炎剂

Abdel-Halim, Mohammad; Abadi, Ashraf H; Engel, Matthias

The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis

ARF 样 GTPase ARFRP1 对脂滴生长至关重要,并参与调节脂肪分解

Angela Hommel, Deike Hesse, Wolfgang Völker, Alexander Jaschke, Markus Moser, Thomas Engel, Matthias Blüher, Claudia Zahn, Alexandra Chadt, Karen Ruschke, Heike Vogel, Reinhart Kluge, Horst Robenek, Hans-Georg Joost, Annette Schürmann