日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A druggable redox switch on SHP1 controls macrophage inflammation

SHP1 上的可药物调控的氧化还原开关控制巨噬细胞炎症

Ng, Mei Ying; Nix, Meredith N; Du, Guangyan; Davidek, Ivan; Burger, Nils; Shin, Sanghee; Toenjes, Sean; Takeda, Haruna; Cheah Xin Yan, Megan; Zhang, Bingsen; Xiao, Haopeng; Wei, Shelley M; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Wales, Thomas E; Engen, John R; Mills, Evanna L; Che, Jianwei; Zhang, Tinghu; Gray, Nathanael S; Chouchani, Edward T

How the non-motile kinesin KIF7 adapts conserved kinesin principles for its function in Hedgehog signaling

非运动性驱动蛋白KIF7如何利用保守的驱动蛋白原理来发挥其在Hedgehog信号通路中的功能

Haque, Farah; Srinivasu, Bindu Y; Engen, John R; Wales, Thomas E; Subramanian, Radhika

Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry

氢氘交换质谱法揭示小分子对多种淀粉样蛋白免疫球蛋白轻链的稳定作用

Peterle, Daniele; Yan, Nicholas L; Klimtchuk, Elena S; Wales, Thomas E; Gursky, Olga; Kelly, Jeffery W; Engen, John R; Morgan, Gareth J

An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck

SH3结合变构调节剂可稳定AML相关Src家族激酶Hck的整体构象。

Selzer, Ari M; Gerlach, Gabriella; Gonzalez-Areizaga, Giancarlo; Wales, Thomas E; Cui, Stephanie Y; Iyer, Prema; Engen, John R; Camacho, Carlos; Ishima, Rieko; Smithgall, Thomas E

Dynamic conformational equilibria in the active states of KRAS and NRAS

KRAS和NRAS活性状态下的动态构象平衡

Rennella, Enrico; Henry, Chrystèle; Dickson, Callum J; Georgescauld, Florian; Wales, Thomas E; Erdmann, Dirk; Cotesta, Simona; Maira, Michel; Sedrani, Richard; Brachmann, Saskia M; Ostermann, Nils; Engen, John R; Kay, Lewis E; Beyer, Kim S; Wilcken, Rainer; Jahnke, Wolfgang

Rigorous Analysis of Multimodal HDX-MS Spectra

对多模态HDX-MS光谱进行严格分析

Tuttle, Lisa M; James, Ellie I; Georgescauld, Florian; Wales, Thomas E; Weis, David D; Engen, John R; Nath, Abhinav; Klevit, Rachel E; Guttman, Miklos

Native Capillary Electrophoresis-Mass Spectrometry of Near 1 MDa Non-Covalent GroEL/GroES/Substrate Protein Complexes

近1 MDa非共价GroEL/GroES/底物蛋白复合物的天然毛细管电泳-质谱分析

Marie, Anne-Lise; Georgescauld, Florian; Johnson, Kendall R; Ray, Somak; Engen, John R; Ivanov, Alexander R

Covalent inhibition of pro-apoptotic BAX.

共价抑制促凋亡蛋白BAX

McHenry Matthew W, Shi Peiwen, Camara Christina M, Cohen Daniel T, Rettenmaier T Justin, Adhikary Utsarga, Gygi Micah A, Yang Ka, Gygi Steven P, Wales Thomas E, Engen John R, Wells James A, Walensky Loren D

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

临床批准的BTK抑制剂对全长BTK构象的影响以及慢性淋巴细胞白血病中BTK耐药突变的发展分析

Joseph, Raji E; Wales, Thomas E; Jayne, Sandrine; Britton, Robert G; Fulton, D Bruce; Engen, John R; Dyer, Martin J S; Andreotti, Amy H

Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin κ1 light chains

互补决定区1和3在人类免疫球蛋白κ1轻链病理性淀粉样蛋白形成中的作用

Klimtchuk, Elena S; Peterle, Daniele; Bullitt, Esther; Connors, Lawreen H; Engen, John R; Gursky, Olga