日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500

鉴定一种新型连接子,用于STING抗体-药物偶联物TAK-500的环状二核苷酸生物偶联

Lee, Hong Myung; Abdul-Hadi, Kojo; Appleman, Vicky A; Cardin, David; Dong, Linlin; England, Dylan; Ganno, Michelle L; Gershman, Rachel; Gigstad, Kenneth; Gulavita, Nanda; Hu, Zhigen; Huang, Jian; Huang, Shih-Chung; Lok, David; Ma, Liting; Malley, Jenna; Mizutani, Miho; Molchanova, Nina; Piatkov, Konstantin I; Rice, Elise; Shi, Zhan; Vyskocil, Stepan; Wang, Jianing; Xu, He; Xu, Tianlin; Zhang, Dong Mei; Zhang, Ji; Abu-Yousif, Adnan O

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

一种强效且选择性的恶性疟原虫酪氨酸 tRNA 合成酶反应劫持抑制剂在体内表现出单剂量口服疗效

Xie Stanley C, Tai Chia-Wei, Morton Craig J, Ma Liting, Huang Shih-Chung, Wittlin Sergio, Du Yawei, Hu Yongbo, Dogovski Con, Salimimarand Mina, Griffin Robert, England Dylan, de la Cruz Elisa, Deni Ioanna, Yeo Tomas, Burkhard Anna Y, Striepen Josefine, Schindler Kyra A, Crespo Benigno, Gamo Francisco J, Khandokar Yogesh, Hutton Craig A, Rabie Tayla, Birkholtz Lyn-Marié, Famodimu Mufuliat T, Delves Michael J, Bolsher Judith, Koolen Karin M J, van der Laak Rianne, Aguiar Anna C C, Pereira Dhelio B, Guido Rafael V C, Creek Darren J, Fidock David A, Dick Lawrence R, Brand Stephen L, Gould Alexandra E, Langston Steven, Griffin Michael D W, Tilley Leann

A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models

一种小分子SUMO化抑制剂可激活抗肿瘤免疫反应,并在临床前模型中增强免疫疗法的疗效。

Lightcap, Eric S; Yu, Pengfei; Grossman, Stephen; Song, Keli; Khattar, Mithun; Xega, Kristina; He, Xingyue; Gavin, James M; Imaichi, Hisashi; Garnsey, James J; Koenig, Erik; Zhang, Hongru; Lu, Zhen; Shah, Pooja; Fu, Yu; Milhollen, Michael A; Hatton, Beryl A; Riceberg, Jessica; Shinde, Vaishali; Li, Cong; Minissale, James; Yang, Xiaofeng; England, Dylan; Klinghoffer, Richard A; Langston, Steve; Galvin, Katherine; Shapiro, Gary; Pulukuri, Sai M; Fuchs, Serge Y; Huszar, Dennis

The Rhodium(II) Carbenoid Cyclization-Cycloaddition Cascade of alpha-Diazo Dihydroindolinones for the Synthesis of Novel Azapolycyclic Ring Systems

铑(II)卡宾环化-环加成级联反应:α-重氮二氢吲哚啉酮的合成及其在新型氮杂多环体系中的应用

England, Dylan B; Eagan, James M; Merey, Gokce; Anac, Olcay; Padwa, Albert

Synthesis of (+/-)-3H-epivincamine via a Rh(II)-triggered cyclization/cycloaddition cascade

通过Rh(II)触发的环化/环加成级联反应合成(+/-)-3H-表乙烯胺

England, Dylan B; Padwa, Albert