文献库，生知库 | 链接生命科学的每一步

日期影响因子

From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models

从样本到混合现实：用于三维细胞培养疾病模型高级三维空间组学分析的转化型三维MALDI成像平台

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202516098

Iakab, Stefania Alexandra; Cordes, Jonas; Enzlein, Thomas; Keller, Florian; Kastner, Kevin; Mulholland, Theresa; Fröhlich, Björn Christian; Gruber, Lars; Cairns, James Lucas; Schmidt, Stefan; Hafner, Mathias; Schneider, Richard; Betge, Johannes; Fischer, Frank; Reichwald, Julian; Rudolf, Rüdiger; Hopf, Carsten

细胞生物学

发表日期：2026

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Deep MALDI-MS spatial omics guided by quantum cascade laser mid-infrared imaging microscopy

量子级联激光中红外成像显微镜引导的深度MALDI-MS空间组学

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-59839-3

Gruber, Lars; Schmidt, Stefan; Enzlein, Thomas; Vo, Huong Giang; Bausbacher, Tobias; Cairns, James Lucas; Ucal, Yasemin; Keller, Florian; Kerndl, Martina; Sammour, Denis Abu; Sharif, Omar; Schabbauer, Gernot; Rudolf, Rüdiger; Eckhardt, Matthias; Iakab, Stefania Alexandra; Bindila, Laura; Hopf, Carsten

多发性硬化症

发表日期：2025

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The relationship between amyloid-β peptide spectrum and the spastic paraparesis phenotype in autosomal dominant Alzheimer's disease

淀粉样β肽谱与常染色体显性遗传阿尔茨海默病痉挛性截瘫表型之间的关系

期刊:Alzheimers Research & Therapy

影响因子:7.6

doi:10.1186/s13195-025-01896-3

Zoltowska, Katarzyna Marta; Bandera, Julia; Hamed, Mohamed Belal; Enzlein, Thomas; Hopf, Carsten; Ryan, Natalie S; Chávez-Gutiérrez, Lucía

阿尔茨海默症

发表日期：2025

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Exploring the Aβ Plaque Microenvironment in Alzheimer's Disease Model Mice by Multimodal Lipid-Protein-Histology Imaging on a Benchtop Mass Spectrometer

利用台式质谱仪进行多模态脂质-蛋白质-组织学成像，探索阿尔茨海默病模型小鼠体内Aβ斑块的微环境

期刊:Pharmaceuticals

影响因子:4.8

doi:10.3390/ph18020252

Müller, Elisabeth; Enzlein, Thomas; Niemeyer, Dagmar; von Ammon, Livia; Stumpo, Katherine; Biber, Knut; Klein, Corinna; Hopf, Carsten

阿尔茨海默症

发表日期：2025

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A sulfatide-centered ultra-high-resolution magnetic resonance MALDI imaging benchmark dataset for MS1-based lipid annotation tools

用于基于 MS1 的脂质注释工具的以硫脂为中心的超高分辨率磁共振 MALDI 成像基准数据集

期刊:Gigascience

影响因子:3.9

doi:10.1093/gigascience/giaf150

Gruber, Lars; Schmidt, Stefan; Enzlein, Thomas; Hopf, Carsten

多发性硬化症

发表日期：2025

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Integrative Single-Plaque Analysis Reveals Signature Aβ and Lipid Profiles in the Alzheimer's Brain

整合单斑块分析揭示阿尔茨海默病脑中特征性的Aβ和脂质谱

期刊:Analytical Chemistry

影响因子:6.7

doi:10.1021/acs.analchem.3c05557

Enzlein, Thomas; Lashley, Tammaryn; Sammour, Denis Abu; Hopf, Carsten; Chávez-Gutiérrez, Lucía

阿尔茨海默症

发表日期：2024

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Label-free assessment of complement-dependent cytotoxicity of therapeutic antibodies via a whole-cell MALDI mass spectrometry bioassay

通过全细胞 MALDI 质谱生物测定法对治疗性抗体的补体依赖性细胞毒性进行无标记评估

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-024-71483-3

Stefan Schmidt #, Alexander Geisel #, Thomas Enzlein, Björn C Fröhlich, Louise Pritchett, Melanie Verneret, Christian Graf, Carsten Hopf

细胞生物学

发表日期：2024

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pyM2aia: Python interface for mass spectrometry imaging with focus on deep learning

pyM2aia：用于质谱成像的 Python 接口，重点关注深度学习

doi:10.1093/bioinformatics/btae133

Cordes, Jonas; Enzlein, Thomas; Hopf, Carsten; Wolf, Ivo

发表日期：2024

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M2ara: unraveling metabolomic drug responses in whole-cell MALDI mass spectrometry bioassays

M2ara：利用全细胞MALDI质谱生物测定法揭示代谢组学药物反应

doi:10.1093/bioinformatics/btae694

Enzlein, Thomas; Geisel, Alexander; Hopf, Carsten; Schmidt, Stefan

细胞生物学

发表日期：2024

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APP substrate ectodomain defines amyloid-β peptide length by restraining γ-secretase processivity and facilitating product release

APP底物胞外结构域通过抑制γ-分泌酶的加工活性并促进产物释放来决定β-淀粉样蛋白肽的长度

期刊:EMBO Journal

影响因子:9.4

doi:10.15252/embj.2023114372

Matthias Koch ，Thomas Enzlein ，Shu-Yu Chen ，Dieter Petit ，Sam Lismont ，Martin Zacharias ，Carsten Hopf ，Lucía Chávez-Gutiérrez

发表日期：2023

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