Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors
功能性患者来源的类器官筛选确定 MCLA-158 是一种治疗性 EGFR × LGR5 双特异性抗体,对上皮性肿瘤有效
期刊:Nature Cancer
影响因子:23.5
doi:10.1038/s43018-022-00359-0
Bram Herpers, Berina Eppink, Mark I James, Carme Cortina, Adrià Cañellas-Socias, Sylvia F Boj, Xavier Hernando-Momblona, Dominik Glodzik, Rob C Roovers, Marc van de Wetering, Carina Bartelink-Clements, Vanessa Zondag-van der Zande, Jara García Mateos, Kuan Yan, Lucia Salinaro, Abdul Basmeleh, Szabol