An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities
一种口服有效的BACE1抑制剂,可在不产生心血管副作用的情况下显著降低中枢神经系统Aβ水平。
期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/ml500458t
Cheng, Yuan; Brown, James; Judd, Ted C; Lopez, Patricia; Qian, Wenyuan; Powers, Timothy S; Chen, Jian Jeffrey; Bartberger, Michael D; Chen, Kui; Dunn, Robert T 2nd; Epstein, Oleg; Fremeau, Robert T Jr; Harried, Scott; Hickman, Dean; Hitchcock, Stephen A; Luo, Yi; Minatti, Ana Elena; Patel, Vinod F; Vargas, Hugo M; Wahl, Robert C; Weiss, Matthew M; Wen, Paul H; White, Ryan D; Whittington, Douglas A; Zheng, Xiao Mei; Wood, Stephen