The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development.
p53 R181C 突变通过 Sirt1 的去乙酰化作用受损而积累，并促进肿瘤发展。
期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-09465-y
Wang Erli, Cao Liangzi, Guo Wendong, Dong Xiang, Zhang Wanying, Zhang Xiaowen, Wang Zhuo, Chen Xia, Li Aicun, Zou Yu, Li Shikun, Chen Kedian, Su Han, Cao Sunrun, Du Ning, Wang Pingyuan, Hwang Paul M, Liu Xiangsheng, Song Xiaoyu, Xu Hongde, Liu Jingwei, Cao Liu
