日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

通过对 MET 受体酪氨酸激酶结构域进行深度突变扫描,揭示了近膜结构域和激酶 N 叶中保守的调控基序

Gabriella O Estevam, Edmond M Linossi, Christian B Macdonald, Carla A Espinoza, Jennifer M Michaud, Willow Coyote-Maestas, Eric A Collisson, Natalia Jura, James S Fraser

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

通过深度突变扫描绘制 MET 受体酪氨酸激酶的激酶结构域抗性机制

Gabriella O Estevam, Edmond M Linossi, Jingyou Rao, Christian B Macdonald, Ashraya Ravikumar, Karson M Chrispens, John A Capra, Willow Coyote-Maestas, Harold Pimentel, Eric A Collisson, Natalia Jura, James S Fraser

Discovering dominant tumor immune archetypes in a pan-cancer census

在泛癌普查中发现主要的肿瘤免疫原型

Alexis J Combes ,Bushra Samad ,Jessica Tsui ,Nayvin W Chew ,Peter Yan ,Gabriella C Reeder ,Divyashree Kushnoor ,Alan Shen ,Brittany Davidson ,Andrea J Barczak ,Michael Adkisson ,Austin Edwards ,Mohammad Naser ,Kevin C Barry ,Tristan Courau ,Taymour Hammoudi ,Rafael J Argüello ,Arjun Arkal Rao ,Adam B Olshen ,Jenny Zhan ,Katelyn C Davis ,Robin K Kelley ,Jocelyn S Chapman ,Chloe E Atreya ,Amar Patel ,Adil I Daud ,Patrick Ha ,Aaron A Diaz ,Johannes R Kratz ,Eric A Collisson ,Gabriela K Fragiadakis ,David J Erle ,Alexandre Boissonnas ,Saurabh Asthana ,Vincent Chan ,Matthew F Krummel

Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors

亚铁激活药物偶联物在 KRAS 驱动的肿瘤中实现了有效的 MAPK 阻断

Honglin Jiang, Ryan K Muir, Ryan L Gonciarz, Adam B Olshen, Iwei Yeh, Byron C Hann, Ning Zhao, Yung-Hua Wang, Spencer C Behr, James E Korkola, Michael J Evans, Eric A Collisson, Adam R Renslo

Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

单细胞转录组分析确定小鼠胰腺导管树的异质性

Audrey M Hendley, Arjun A Rao #, Laura Leonhardt #, Sudipta Ashe #, Jennifer A Smith, Simone Giacometti, Xianlu L Peng, Honglin Jiang, David I Berrios, Mathias Pawlak, Lucia Y Li, Jonghyun Lee, Eric A Collisson, Mark S Anderson, Gabriela K Fragiadakis, Jen Jen Yeh, Chun Jimmie Ye, Grace E Kim, Valer

Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer

RAS-MAPK 通路同时发生的改变限制了 MET 外显子 14 跳跃突变阳性肺癌患者对 MET 抑制剂治疗的反应

Julia K Rotow, Philippe Gui, Wei Wu, Victoria M Raymond, Richard B Lanman, Frederic J Kaye, Nir Peled, Ferran Fece de la Cruz, Brandon Nadres, Ryan B Corcoran, Iwei Yeh, Boris C Bastian, Petr Starostik, Kimberly Newsom, Victor R Olivas, Alexander M Wolff, James S Fraser, Eric A Collisson, Caroline E

Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer

阻断白血病抑制因子作为治疗 KRAS 驱动的胰腺癌的方法

Man-Tzu Wang, Nicole Fer, Jacqueline Galeas, Eric A Collisson, Sung Eun Kim, Jeremy Sharib, Frank McCormick

MET Exon 14 Mutation Encodes an Actionable Therapeutic Target in Lung Adenocarcinoma

MET 外显子 14 突变编码了肺腺癌的可行治疗靶点

Xinyuan Lu, Nir Peled, John Greer, Wei Wu, Peter Choi, Alice H Berger, Sergio Wong, Kuang-Yu Jen, Youngho Seo, Byron Hann, Angela Brooks, Matthew Meyerson, Eric A Collisson

Stromal cues regulate the pancreatic cancer epigenome and metabolome

基质线索调节胰腺癌表观基因组和代谢组

Mara H Sherman, Ruth T Yu, Tiffany W Tseng, Cristovao M Sousa, Sihao Liu, Morgan L Truitt, Nanhai He, Ning Ding, Christopher Liddle, Annette R Atkins, Mathias Leblanc, Eric A Collisson, John M Asara, Alec C Kimmelman, Michael Downes, Ronald M Evans

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

基因型调节胰腺导管腺癌组织张力,从而诱导基质细胞纤维化和肿瘤进展

Hanane Laklai ,Yekaterina A Miroshnikova ,Michael W Pickup ,Eric A Collisson ,Grace E Kim ,Alex S Barrett ,Ryan C Hill ,Johnathon N Lakins ,David D Schlaepfer ,Janna K Mouw ,Valerie S LeBleu ,Nilotpal Roy ,Sergey V Novitskiy ,Julia S Johansen ,Valeria Poli ,Raghu Kalluri ,Christine A Iacobuzio-Donahue ,Laura D Wood ,Matthias Hebrok ,Kirk Hansen ,Harold L Moses ,Valerie M Weaver